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EC number: 202-794-6 | CAS number: 99-85-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- p-mentha-1,4-diene
- EC Number:
- 202-794-6
- EC Name:
- p-mentha-1,4-diene
- Cas Number:
- 99-85-4
- Molecular formula:
- C10H16
- IUPAC Name:
- p-mentha-1,4-diene
Constituent 1
- Specific details on test material used for the study:
- Test Item: Gamma Terpinene
Lot Number: 161215
Purity: 98 %
CAS No 99-85-4
EINECS-No 02-794-6
Appearance: Clear, liquid
Composition: Gamma Terpinene
Production Date: 15 December 2016
Expiry Date: 14 December 2018
Storage: Room temperature (20 ± 5°C); keep away of light
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- The animals were observed individually immediately after the administration of the test item and
then 0.5, 1, 2, and 4 hours later. Then each animal was inspected daily for the next 14 days. - Doses:
- The starting dose could be selected from the fixed dose levels of 5, 50, 300, and 2000 mg/kg body
weight. Available information indicated that the test item is likely to be non-toxic with regard to
acute toxicity. A limit dose of 2000 mg/kg body weight was used as a starting dose. - No. of animals per sex per dose:
- 6
- Details on study design:
- The purpose of the study was to evaluate the potential toxic effect of the test item Gamma
Terpinene after single oral administration in rats. The procedure according to OECD Guideline 423
Acute Toxic Class Method was used. The ATC method is not designed to determine a point
estimate of LD50. It provides a range estimate of LD50 defined by cut-off values of the applied
classification system and not as a calculated lower and upper level. The method provides
information on hazardous properties and allows the test item to be ranked and classified according
to the Globally Harmonised System (GHS) of Classification and Labelling of Chemicals.
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality was observed during the study
- Clinical signs:
- other: No mortality was observed during the study. During the follow up period, no animals displayed signs of intoxication, change of health, nor any other adverse reaction.
- Gross pathology:
- All animals were necropsied. During necropsy, no macroscopic findings were observed.
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- The test item Gamma Terpinene administered to 6 females at dose of 2000 mg/kg body weight did
not cause death. No signs of toxicity were observed during the first 4 hours in females or the 14-day
observation period thereafter. No body weight losses were observed between one and two weeks
after administration of the test item. During necropsy, no macroscopic findings were observed.
The LD50 of the test item Gamma Terpinene is greater than 2000 mg/kg body weight after single
oral administration to Wistar rats.
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