Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 701-040-8 | CAS number: 59952-43-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Guidance on Safe Use
Administrative data
First-aid measures
General advice: Soiled, soaked clothing and shoes must be immediately removed, decontaminated and disposed of.
If inhaled: If inhaled, remove to fresh air. If not breathing, give artificial respiration. Get medical attention immediately.
In case of skin contact: In the event of contact with the skin, preferably wash with a cleanser based on polyethylene glycol or with plenty of warm water and soap. Consult a doctor in the event of a skin reaction. Wash clothing before reuse. Clean shoes
thoroughly before reuse.
In case of eye contact: Hold the eyes open and rinse with preferably lukewarm water for a sufficiently long period of time (at least 10 minutes). Get medical attention immediately.
If swallowed: DO NOT induce the patient to vomit, medical advice is required. Never give anything by mouth to an unconscious person. Provided the patient is conscious,
wash out mouth with water.
Notes to physician: The product irritates the respiratory tract and may trigger sensitisation of the skin and respiratory tract. Treatment of acute irritation or bronchial constriction is primarily symptomatic. Following severe exposure the patient should be kept under medical review for at least 48 hours.
Fire-fighting measures
Suitable extinguishing media: Foam, CO2 or dry powder. Water spray may be used if no other available and then in copious quantities. Reaction between water and hot isocyanate may be vigorous. Prevent washings from entering water courses, keep fire exposed containers cool by spraying with water.
Unsuitable extinguishing media: High volume water jet.
Combustion products may include: carbon oxides (CO, CO2) nitrogen oxides (NO, NO2 etc.) hydrocarbons, isocyanate vapors and hydrogen cyanide.
In the event of fire and/or explosion do not breathe fumes.
Fire in vicinity poses risk of pressure build-up and rupture. Containers at risk from fire should be cooled with water and, if possible, removed from the danger area. Due to reaction with water producing CO2-gas, a hazardous build-up of pressure could result if contaminated containers are re-sealed. Containers may burst if overheated.
Fire-fighters should wear appropriate protective equipment and self-contained breathing apparatus (SCBA) with a full face-piece operated in positive pressure mode. PVC boots, gloves, safety helmet and protective clothing should be worn.
Do not allow contaminated extinguishing water to enter the soil, ground-water or surface waters.
Accidental release measures
Personal precautions: Immediately contact emergency personnel. Evacuate the area. Keep upwind to avoid inhalation of vapours. Clean-up should only be performed by trained personnel. People dealing with major spillages should wear full protective clothing including respiratory protection. Use suitable protective equipment (section 8). Keep unauthorized persons away.
Environmental precautions: Avoid dispersal of spilt material and runoff and contact with soil, waterways, drains and sewers.
Methods for cleaning up: If the product is in its solid form: Spilled MDI flakes should be picked up carefully. The area should be vacuum cleaned to remove remaining dust particles completely.
If the product is in its liquid form: Absorb spillages onto sand, earth or any suitable adsorbent material. Leave to react for at least 30 minutes. Do not absorb onto sawdust or other combustible materials. Shovel into open-top drums for further decontamination. Wash the spillage area with water. Test atmosphere for MDI vapour. Neutralise small spillages with decontaminant. Remove and dispose of residues. The compositions of liquid decontaminants are : (percentages by weight or volume) :
Decontaminant 1 : *- sodium carbonate : 5 - 10 % *- liquid detergent : 0.2 - 2 % *- water : to make up to 100 %
Decontaminant 2 : *- concentrated ammonia solution : 3 - 8 % *- liquid detergent : 0.2 - 2 % *- water : to make up to 100 %
Decontaminant 1 reacts slower with diisocyanates but is more environmentally friendly than decontaminant 2.
Decontaminant 2 contains ammonia. Ammonia presents health hazards. (See supplier safety information.)
Additional advice: -
Handling and storage
Handling: Provide sufficient air exchange and/or exhaust in work rooms. In all workplaces or parts of the plant where high concentrations of isocyanate aerosols and/or vapors may be generated (e.g. during pressure release, mold venting or when cleaning mixing heads with an air blast), appropriately located exhaust ventilation must be provided in order to prevent occupational exposure limits from being exceeded. The air should be drawn away from the personnel handling the product.
The efficiency of the ventilation system must be monitored regularly because of the possibility of blockage.
Atmospheric concentrations should be minimised and kept as low as reasonably practicable below the occupational exposure limit.
Contact with skin and eyes and inhalation of vapors must be avoided under all circumstances.
Keep equipment clean.
A basic essential in sampling, handling and storage is the prevention of contact with water. Keep stocks of decontaminant readily available. The compositions of liquid decontaminants are described under "Accidental release measures".
Storage : Store in accordance with local regulations. Store in original container protected from direct sunlight in a dry, cool and well-ventilated area, away from incompatible materials and food and drink. Keep container tightly closed and sealed until ready for use. Containers that have been opened must be carefully resealed and kept upright to prevent leakage. Do not store in unlabelled containers.
Use appropriate containment to avoid environmental contamination.
Suitable containers: Steel. Stainless steel.
Unsuitable containers: Copper., copper alloy and galvanised surfaces
Transport information
Land transport (UN RTDG/ADR/RID)
- UN number:
- Not dangerous goods
Shippingopen allclose all
SpecialProvisionsopen allclose all
Inland waterway transport (UN RTDG/ADN(R))
- UN number:
- Not dangerous goods
Shippingopen allclose all
Remarksopen allclose all
Marine transport (UN RTDG/IMDG)
- UN number:
- Not dangerous goods
Shipping information
- Proper shipping name and description:
- Not dangerous goods
- Chemical name:
- Not dangerous goods
- Labels:
- Not dangerous goods
Remarksopen allclose all
Air transport (UN RTDG/ICAO/IATA)
- UN number:
- Not dangerous goods
Shipping information
- Proper shipping name and description:
- Not dangerous goods
- Chemical name:
- Not dangerous goods
- Labels:
- Not dangerous goods
Remarksopen allclose all
SpecialProvisionsopen allclose all
Exposure controls / personal protection
not required
Stability and reactivity
not required
Disposal considerations
not required
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.