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EC number: 830-560-9 | CAS number: 2233585-18-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guidelines for Testing of Chemicals, Section 4, OECD Publishing. DOI: 10.1787/9789264071001-en.
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- (2E,2'E)-2,4,8,10-tetraoxaspiro[5.5]undecane-3,9-diylbis(2-methylpropane-2,1-diyl) bis(2-cyano-3-(3,4-dimethoxyphenyl)acrylate)
- Cas Number:
- 2233585-18-5
- Molecular formula:
- C39H46N2O12
- IUPAC Name:
- (2E,2'E)-2,4,8,10-tetraoxaspiro[5.5]undecane-3,9-diylbis(2-methylpropane-2,1-diyl) bis(2-cyano-3-(3,4-dimethoxyphenyl)acrylate)
- Test material form:
- solid
- Remarks:
- Light yellow solid (powder)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- Animals were fasted overnight prior to dosing orally. The dosing volume was calculated based on the individual body weight on D1 before dosing. Three females were dosed of 2000 mg/kg first, and then three more females were administered at 5 days later since no mortality was observed on the first three animals. Total 6 animals were administered test article at dose level of 2000 mg/kg. After the test article administration, food was withheld for a further 3 to 4 hours.
- No. of animals per sex per dose:
- Animals were fasted overnight prior to dosing orally. The dosing volume was calculated based on the individual body weight on D1 before dosing. Three females were dosed of 2000 mg/kg first, and then three more females were administered at 5 days later since no mortality was observed on the first three animals. Total 6 animals were administered test article at dose level of 2000 mg/kg. After the test article administration, food was withheld for a further 3 to 4 hours.
Results and discussion
- Preliminary study:
- Treated animals were observed by detailed clinical examinations at 0.5 and 4 hours after dosing on D1, and once weekly starting from the dosing day to the day before necropsy. Other days, exception of Day 6, cage-side observation was conducted. The clinical observation on Day 6 for ID#1, 2, 3 was not conducted. All animals were normal on Day 5 and Day 7. The one day data missing did not have impact on the outcome of study.
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- 0
- Body weight:
- Body weight was recorded on animals treated with test article, prior to the start of dosing (D1), D8, at the end of the study period (D15).
Any other information on results incl. tables
Mortality and moribundity
Mortality and moribundity of animals were checked twice daily from Days 1 to 15 except necropsy day on which mortality and moribundity were checked only once before necropsy.
Clinical observations
Treated animals were observed by detailed clinical examinations at 0.5 and 4 hours after dosing on D1, and once weekly starting from the dosing day to the day before necropsy. Other days, exception of Day 6, cage-side observation was conducted. The clinical observation on Day 6 for ID#1, 2, 3 was not conducted. All animals
were normal on Day 5 and Day 7. The one day data missing did not have impact on the outcome of study.
Body weights
Body weight was recorded on animals treated with test article, prior to the start of dosing (D1), D8, at the end of the study period (D15).
Gross necropsy
[SOP: CTPS-TE00449]
Gross necropsy was performed on all rats at the end of study (D15). The rats were euthanized by carbon dioxide exposure followed by exsanguinations and necropsied. The external surface of the body and all organs/tissues in the thoracic and abdominal cavities were examined.
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- A single oral dose of “Chiguard® GA403” (Lot no.: S323B185001) was given to six female rats at 2000 mg/kg, none animal was found dead.
- Executive summary:
“Chiguard® GA403” (Lot no.: S323B185001) in GHS system and the harmonized LD50 cut-off values are classified to category 5/unclassified and 5000 mg/kg, respectively.
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