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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 701-338-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- guideline study under GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 016
- Report date:
- 2016
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 425 (Acute Oral Toxicity: Up-and-Down Procedure)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- up-and-down procedure
- Limit test:
- yes
Test material
- Reference substance name:
- 3-[(2E)-octadec-2-en-1-yl]dihydrofuran-2,5-dione
- Cas Number:
- 1628163-42-7
- Molecular formula:
- C22H38O3
- IUPAC Name:
- 3-[(2E)-octadec-2-en-1-yl]dihydrofuran-2,5-dione
- Reference substance name:
- 3-[(2Z)-octadec-2-en-1-yl]dihydrofuran-2,5-dione
- Molecular formula:
- C22H38O3
- IUPAC Name:
- 3-[(2Z)-octadec-2-en-1-yl]dihydrofuran-2,5-dione
- Reference substance name:
- 3-(octadecenyl)dihydrofuran-2,5-dione excluding 3-(2-octadecen-1-yl)dihydrofuran-2,5-dione
- Molecular formula:
- C22H38O3
- IUPAC Name:
- 3-(octadecenyl)dihydrofuran-2,5-dione excluding 3-(2-octadecen-1-yl)dihydrofuran-2,5-dione
- Reference substance name:
- Hexadecenylsuccinic anhydride
- EC Number:
- 250-911-4
- EC Name:
- Hexadecenylsuccinic anhydride
- Molecular formula:
- C20H34O3
- IUPAC Name:
- 3-(hexadecenyl)dihydrofuran-2,5-dione
- Reference substance name:
- 3-icosenylsuccinic anhydride
- EC Number:
- 258-603-1
- EC Name:
- 3-icosenylsuccinic anhydride
- Molecular formula:
- C24H42O3
- IUPAC Name:
- 3-icosenyldihydrofuran-2,5-dione
- Reference substance name:
- Side products from the reaction of octadec-1-ene and maleic anhydride
- Molecular formula:
- Not applicable - UVCB component
- IUPAC Name:
- Side products from the reaction of octadec-1-ene and maleic anhydride
- Reference substance name:
- C16-20 (even numbered) alkenes (branched and linear)
- Molecular formula:
- C16H32, C18H36, C20H40
- IUPAC Name:
- C16-20 (even numbered) alkenes (branched and linear)
- Reference substance name:
- Maleic anhydride
- EC Number:
- 203-571-6
- EC Name:
- Maleic anhydride
- Cas Number:
- 108-31-6
- Molecular formula:
- C4H2O3
- IUPAC Name:
- furan-2,5-dione
- Test material form:
- solid
- Details on test material:
- off-white solid, amber liquid at 80 °C. Expected to be stable for duration of testing; Expiration date: not applicable.
Constituent 1
Constituent 2
Constituent 3
Constituent 4
Constituent 5
Constituent 6
Constituent 7
Constituent 8
- Specific details on test material used for the study:
- As a result of increasingly rigorous criteria being applied to the analysis of commercial material used in physical property/toxicity testing, the identity of the material has been modified to reveal a more accurate and precise depiction of the commercial substance. This enhancement is reflected in changes in chemical identifiers such as EC and/or CAS numbers from those noted in earlier versions of data records or in study reports.
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Laboratories, Inc.
- Age at study initiation: 8-12 weeks
- Weight at study initiation:
- Fasting period before study: no
- Housing: nimals will be housed singly in suspended stainless steel perforated bottom cages or plastic solid bottom cages. Litter paper placed beneath the cage will be changed at least three times/week or Corncob bedding (1/4 inch bed-o'-cobs®, or equivalent) will be changed at least once per week.
- Diet (e.g. ad libitum): Harlan Teklad Global 16% Protein Rodent Diet® #2016, ad libitum.
- Water (e.g. ad libitum): tap water, ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 23 +/- 3C
- Humidity (%): 30-70%,
- Air changes (per hr): 10
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: To:
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- Several trials were undertaken to solubilize this waxy solid test material in a suitable vehicle for oral gavage administration to rats. Care needed to be taken to avoid aqueous solvents, as the material hydrolyses in water. The substance was gently warmed to 80 degrees C and solubilized in corn oil, which, when cool, was administered to the animals.
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- Limit Test at 2000 mg/kg: If the initial animal survives following dosing, the test substance will be administered sequentially to four additional females so that a total of five animals are dosed; however, if at any time three animals die, the limit test will be terminated and the main test will be conducted. If an animal dies late in the observation period, all dosing should be stopped and the animals already on test should be observed for a similar period prior to proceeding. The LD50 of the test substance will be considered greater than the limit dose if three or more animals out of five survive.
- Statistics:
- Dose progression and stopping criteria will be calculated using a dedicated software program (Acute Oral Toxicity (Guideline 425) Statistical Program) provided by the U.S. Environmental Protection Agency (EPA).
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No deaths; LD0 > 2000 mg/kg bw.
- Mortality:
- No deaths occurred at 2000 mg/kg bw. The LD50 is greater than 2000 mg/kg bw.
- Clinical signs:
- other: No signs of toxicity
- Gross pathology:
- No findings on gross pathology
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Migrated information: The LD50 is greater than 2000 mg/kg bw, and so is not classified according to Regulation EC No. 1272/2008.
- Conclusions:
- n-ODSA was tested in an OECD 425 Up-and-down protocol according to GLP, and the LD50 was found to be greater than 2000 mg/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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