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Diss Factsheets
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EC number: 221-904-3 | CAS number: 3275-24-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is a strong acid (pH ≤ 2.0) or base (pH ≥ 11.5) and the available information indicates that it should be classified as skin corrosion (Category 1, 1A, 1B or 1C)
- Justification for type of information:
- Titanium tetrakic(dimethylammonium) is an organometalic liquid with an pH > 11. The substance is classified as corrosive (Skin Corr 1B, H314 and Eye Damage 1, H 318). Additionally, titanium tetrakic(dimethylammonium) can only be handled in air-free environments. It is a flammable liquid and extremely unstable (see also chapter 1.2 or 5.1.2 or 13). Within seconds, it reacts violently in contact with moisture or water. The decomposition products are dimethylamine and titanium oxide. Dimethylamine is a highly flammable gas, but dimethylamine is well water soluble, highly basic, and corrosive to skin and eyes. In an acute inhalation toxicity study with dimethylamine (Steinhagen et al.), severe corrosive and necrotic effects were observed on eyes, skin, and mucous nasal membranes
Cross-reference
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- not specified
- Test type:
- other: acute inhalation toxicity
- Limit test:
- no
- Specific details on test material used for the study:
- dimethylamine was applied as gas
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- rats from Charles River Breeding Labs, Kingston, NY
weight: 158-218 grams
before and after exposure rats were housed in stainless steal wire mash cages with false floors. Animal rooms were maintained at 20-24°C with 45-60% humidity and a 12 hour on/off light cycle. Exept during exposure, animals were provided water and food (Wayne Lab Blocks Chicago, IL) ad libitum - Route of administration:
- inhalation: gas
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: nitrogen
- Details on inhalation exposure:
- Tte animals were exposed in a 99 liter glass and teflon whole body exposure chamber
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 6 h
- Remarks on duration:
- observation period untill 48 hours after exposure
- Concentrations:
- 600; 1000; 2500; 4000; 6000 ppm
- No. of animals per sex per dose:
- ca 10 animals per dose
- Control animals:
- not specified
- Statistics:
- According to Litchfield and Wilcoxon (1949)
The LC50 was determined and analyzed using probit and Chi2 analysis. All results were considered significant at p <= 0.05 - Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 4 540 ppm
- Based on:
- test mat.
- 95% CL:
- ca. 4 208 - ca. 4 899
- Exp. duration:
- 6 h
- Mortality:
- concentraions of 600; 1000; and 2000 ppm produced no mortality
mortality starting from 4000 ppm with a 90% mortality at 6000 ppm - Clinical signs:
- other: eye irritation, gasping, bloody nose secretion, salivation, lacrimation, corneal opacity, convulsion
- Gross pathology:
- all dose groups: severe congestion, ulcerative rhinits and necrosis of the nasal turbinates,
rats exposed to 2500 ppm DMA showed ulcerative tracheitis with pseudomembrane formation, bacterial colonization, epithelial hyperplasia,
exposure to 1000 ppm caused suppurative tracheitis with epithelial hyperplasia, at 600 ppm mild tracheitis and epithelial hyperplasia,
lungs: at 4000 to 6000 ppm: ulcerative lesions that extended to the level of primary and secondary bronchioles, at 2500 to 6000: ppm peripheral emphysema and bronchopneumonia, at 1000 ppm: emphysema, bronchial hyperplasia, pneumonitis, at 600 ppm: mild emphysema in peripheral areas of the lung
Lesions outside the respiratory tract were evident in livers at 2500 to 6000 ppm and the eyes of animals at 1000 to 6000 ppm, hepatic lesions consisted of mild fatty degeneration and focal necrosis at 2000 to 4000 ppm and one 6000 ppm animal showed centrolobular necrosis
Ocular pathology increased in severity with exposure concentrations. at 1000 ppm corneal edema was evident, at 2500 to 6000 ppm corneal ulceration, keratitis, edema and loss of Descement's membrane, many rats exposed to 4000 or 6000 ppm showed necrosis of the iris and severe degeneration of the lens, suggestive or acute cataract formation - Executive summary:
An LC50 of 4500 ppm was determined in rats after 6 h whole body exposure with dimethylamine gas.
The observed concentration-dependent effects can be related to the corrosive properties of dimethylamine
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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