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Physical & Chemical properties

Water solubility

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water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2008-12-15 to 2009-03-23
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation
The study was conducted according to an internationally recognised method, and under GLP. No deviation affected the quality of the study. However, some experimental details are missing.
according to guideline
OECD Guideline 105 (Water Solubility)
Version / remarks:
27th July 1995
according to guideline
EU Method A.6 (Water Solubility)
Version / remarks:
Council Regulation (EC) No 440/2008 of 30 May 2008
GLP compliance:
yes (incl. QA statement)
Inspected on 14 September 2010 / Signed on 07 February 2011
Type of method:
flask method
Specific details on test material used for the study:
Storage condition of test material: room temperature.
Key result
Water solubility:
999 µg/L
Conc. based on:
test mat.
Loading of aqueous phase:
110 mg/L
Incubation duration:
>= 24 - <= 144 h
20 °C
Remarks on result:
other: pH was not recorded

Individual results are shown in the following table.

 Stirring time* Concentration [μg/L]  Mean -15%  Mean +15%
 at 20°C [h]  vessel 1  vessel 2  vessel 3  mean  [μg/L]  [μg/L]
 24  (796.2)** 971.5  923.3 947.4 805.3  1089.5
 48 916.9  1048.9  1061.9 1009.3 857.9  1160.6 
 72 1001.1  960.1  1042.7 1001.3 851.1  1151.5 
 144 1101.8  953.8  1006.7 1020.8 867.7  1173.9 
Overall mean (calc. from single values):  999.0    

*after initial stirring time of 24 h at 30°C ** outlier (value not considered)

The results obtained at the 4 sampling times were in agreement (did not differ by more than 15 %). No tendency to increasing values with increasing equilibration times was observed. So the equilibration times used were long enough according to the test guideline and the test was satisfactory.

Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
Executive summary:

The water solubility of the test substance was measured according to the OECD 105/EU A6 guideline, flask method.

Triplicate vessels were incubated with ca 110 mg/L at 30°C for 24h, then equilibrated at 20°C for 24 to 144h, with slow-stirring. Samples were extracted and analysed by GC-AED, calibrated with 6 standard solutions and an internal standard substance. Results were consistent (repeatability < 15%), so equilibrium was considered to be reached.

The water solubility (mean of 4 sampling times) was determined as 0.999 mg/L at 20°C.

Description of key information

The substance is considered to be slightly soluble in water.

Key value for chemical safety assessment

Water solubility:
0.999 mg/L
at the temperature of:
20 °C

Additional information

A reliable experimental study, conducted according to a recognized OECD/EC method and under GLP, is available. Despite restrictions on experimental details, it is considered as a key study, and the result is retained as key data.