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Diss Factsheets
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EC number: 849-166-3 | CAS number: 83841-00-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Particle size distribution (Granulometry)
Administrative data
Link to relevant study record(s)
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: European Commission Technical Guidance Document EUR 20268
- Version / remarks:
- Determination of Particle Size Distribution, Fibre Length and Diameter Distribution of Chemical Substances (2002).
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- cascade impaction
- Type of particle tested:
- primary particle
- Type of distribution:
- mass based distribution
- Mass median aerodynamic diameter:
- 10.6 µm
- Geometric standard deviation:
- 2.51
- Remarks on result:
- not measured/tested
- Conclusions:
- The mean achieved mass median aerodynamic diameter of the substance, determined by casade impaction, was 10.6 μm and in the range of 7.1 μm to 12.8 μm, with a geometric standard deviation of 2.51.
- Executive summary:
The particle size distribution of the substance was determined under GLP by cascade impaction in accordance with European Commission Technical Guidance Document EUR 20268, Determination of Particle Size Distribution, Fibre Length and Diameter Distribution of Chemical Substances (2002).
The particle size distribution of the test substance was determined by cascade impaction at a target aerosol concentration of 2.0 mg/L. The study was performed in a flow through snout-only chamber. A solid aerosol generator was used to generate the aerosols for the test. The SAG mechanism technique for the dispersion of dry dust and powders comprises two steps, the continuous supply of material to the disperser and the dispersal of the material as an aerosol. The method for metering powder to the disperser was to use a moving toothed belt. A regulated flow of compressed air conducted the aerosol to the inhalation chamber. The test system was housed in a ventilated cabinet. Aerosols were collected with glass microfibre filters, held in an open faced filter holder. The sample volume was measured by a wet-type gas meter. The sample analysis was done by gravimetry. The particle size distribution and mass median aerodynamic diameters (MMAD) were determined by cascade impaction. Stainless steel substrates and glass microfibre final stage filter were used. MMAD and geometric standard deviation were calculated by linear regression of the probit of the cumulative percentage, by mass, of particles smaller than the effect cut-off diameter (ECD) of each stage versus the logarithm of the ECD of each stage. Generation of aerosol concentrations of the test substance using the SAG generation device was variable, it was noted during generation that the belt speed was often variable due to the test item blocking the belt movement. This resulted in inconsistent achieved aerosol concentrations.
Reference
Table 1: details on aerosol concentrations
Stage |
Percentage of sample collected on each stage Trial number |
|||
1 |
2 |
3 |
Mean |
|
1 |
18.5 |
6.6 |
17.1 |
14.1 |
2 |
20.0 |
6.6 |
24.4 |
17.0 |
3 |
28.3 |
26.2 |
31.7 |
28.7 |
4 |
24.4 |
39.3 |
14.6 |
26.1 |
5 |
4.4 |
8.2 |
6.1 |
6.2 |
6 |
3.9 |
4.9 |
3.7 |
4.2 |
7 |
0.5 |
6.6 |
2.4 |
3.2 |
8 |
0.0 |
1.6 |
0.0 |
0.5 |
Filter |
0.0 |
0.0 |
0.0 |
0.0 |
MMAD |
12.6 |
7.1 |
12.8 |
10.6 |
Geometric standard deviation |
2.12 |
2.42 |
2.49 |
2.51 |
Generation of aerosol concentrations of the test substance using the SAG generation device was variable, it was noted during generation that the belt speed was often variable due to the test item blocking the belt movement. This resulted in inconsistent achieved aerosol concentrations.
Description of key information
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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