Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-321-6 | CAS number: 105-67-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1955
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The water solubility of the test substance was determined using the flask method. The test substance was dissolved in distilled water containing 0.8 g/L of potassium dihydrogen phosphate so that the buffering capacity was the same as in the culture solution for L. minor. Excess of the test substance was shaken up with about 100 or 200 mL. of the solvent in a bottle with a ground-glass stopper, and the bottle was then placed in a thermostat at 25°C. Each bottle was shaken periodically, and after 2 days the pH was adjusted to 5.1. This adjustment was repeated until the pH remained constant-usually after about a week-but the bottles with further shaking were left for at least an additional fortnight to ensure that the solutions were completely saturated. The the concentration of the test substance was determined by a suitable analytical method
- GLP compliance:
- not specified
- Type of method:
- flask method
- Key result
- Water solubility:
- 8 790 mg/L
- Temp.:
- 25 °C
- pH:
- 5.1
- Conclusions:
- Under the study conditions, the water solubility of the test substance was determined to be 8790 mg/L at 25°C
- Executive summary:
A study was conducted to determine the water solubility of the test substance using the flask method. Under the study conditions, the water solubility of the test substance was determined to be 8790 mg/L at 25°C (Blackman, 1955).
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- An excess of the test substance was added to a tube containing distilled water, and the tube was sealed and allowed to equilibriate at 25 ±0.2 degree C with constant or intermittent shaking. The solubility of test substance were analysed by using liquid scintillation counting (LSC)
- GLP compliance:
- not specified
- Type of method:
- flask method
- Key result
- Water solubility:
- 7 870 mg/L
- Temp.:
- 25 °C
- Remarks on result:
- other: High water solubility
- Conclusions:
- Under the study conditions, the water solubility of the test substance was determined to be 7870 mg/L at 25°C
- Executive summary:
A study was conducted to determine the water solubility of the test substance using the flask method. An excess of the test substance was added to a tube containing distilled water, and the tube was sealed and allowed to equilibriate at 25 ±0.2 degree C with constant or intermittent shaking. The solubility of test substance were analysed by using liquid scintillation counting (LSC). The entire procedure was carried out at least twice for each test substance, and each analysis was also conducted in duplicate. Under the study conditions, the water solubility of the test substance was determined to be 7870 mg/L at 25°C ( Banerjee, 1955).
Referenceopen allclose all
Description of key information
The water solubility of the test substance was determined using the flask methods (Blackman, 1955; Baerjee, 1980).
Key value for chemical safety assessment
- Water solubility:
- 8 790 g/L
- at the temperature of:
- 25 °C
Additional information
The water solubility values of the test substance were determined to range from 7870 to 8790 mg/L at 25°C. The higher water solubility value which would maximise the exposure to environmental compartments has been considered further for hazard/risk assessment as a conservative approach.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.