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EC number: 432-770-2 | CAS number: 139189-30-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 24 Aug and 7 Sept 1999
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of relevant results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- UK GLP standards (Schedule 1, Good Laboratory Practice Regulations 1997 (SI 1997/654)).
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 432-770-2
- EC Name:
- -
- Cas Number:
- 139189-30-3
- Molecular formula:
- C38 H40 O8 P2
- IUPAC Name:
- 3-{[bis(2,6-dimethylphenoxy)phosphoryl]oxy}phenyl bis(2,6-dimethylphenyl) phosphate
- Reference substance name:
- Tetrakis (2,6-dimethylphenyl)-m-phenylene biphosphate
- IUPAC Name:
- Tetrakis (2,6-dimethylphenyl)-m-phenylene biphosphate
- Details on test material:
- - Name of test material (as cited in study report): PX-200- Molecular formula (if other than submission substance): same as submission substance- Molecular weight (if other than submission substance): same as submission substance- Smiles notation (if other than submission substance): same as submission substance- InChl (if other than submission substance): same as submission substance- Structural formula attached as image file (if other than submission substance): same as submission substance- Substance type: white powder- Physical state: solid- Analytical purity: not stated- Impurities (identity and concentrations): not stated- Composition of test material, percentage of components: not stated- Isomers composition: not stated- Purity test date: not stated- Lot/batch No.:F10303- Expiration date of the lot/batch: not stated- Radiochemical purity (if radiolabelling): not stated- Specific activity (if radiolabelling): not stated- Locations of the label (if radiolabelling): not stated- Expiration date of radiochemical substance (if radiolabelling): not stated- Stability under test conditions: not stated- Storage condition of test material: room temperature- Other: not stated- Storage condition of test material: - Other:
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS- Source: Charles River (UK) Ltd., Margate, Kent, UK.- Age at study initiation: Approximately 8 to 12 weeks.- Weight at study initiation: Males = 205 to 223 gm, Females = 204 to 212 gm.- Fasting period before study: No.- Housing: Suspended polypropylene cages furnished with wood flakes.- Diet: ad libitum- Water: ad libitum- Acclimation period: minimum period of five days.ENVIRONMENTAL CONDITIONS- Temperature (°C): 19 to 25°C- Humidity (%): 30 to 70%- Air changes (per hr): 15 changes per hour.- Photoperiod (hrs dark / hrs light): 12 hours continuos light, followed by 12 hours continuous darkIN-LIFE DATES: From: Day 1 To: Day 14
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- arachis oil
- Details on dermal exposure:
- TEST SITE- Area of exposure: Back and flanks- % coverage: 10%- Type of wrap if used: Surgical gauze with a self adhesive bandage. REMOVAL OF TEST SUBSTANCE- Washing (if done): Arachis Oil BP used to remove any residual test material.- Time after start of exposure: 4 hoursTEST MATERIAL- Amount(s) applied (volume or weight with unit): Exact amount not stated in report. - Concentration (if solution): Not applicable.- Constant volume or concentration used: Yes- For solids, paste formed: Not stated in report. Was moistened with Arachis Oil BP.VEHICLE- Amount(s) applied (volume or weight with unit):Not stated in report.- Concentration (if solution): Not stated in report.- Lot/batch no. (if required): Not stated in report.- Purity: Not stated in report.
- Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5 males / 5 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days - Frequency of observations and weighing: Observed for deaths or overt signs of toxicity at 0.5 hrs, 1, 2 and 4 hours after dosing, and subsequently once daily for 14 days.- Necropsy of survivors performed: yes- Other examinations performed: clinical signs, body weight, histopathology, other: dermal reactions
- Statistics:
- Not applicable.
Results and discussion
- Preliminary study:
- Not applicable.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- There were no deaths.
- Clinical signs:
- other: No signs of systemic toxicity were noted.
- Gross pathology:
- No abnormalities were noted at necropsy.
- Other findings:
- - Organ weights: Not recorded.- Histopathology: Not recorded.- Potential target organs: None.- Other observations: None
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated informationCriteria used for interpretation of results: EU
- Conclusions:
- The acute dermal median lethal dose (LD50) of the test material, PX-200, in the Sprague-Dawley CD strain rat was found to be greater than 2000 mg/kg/bw. No symbol and risk phrases are required according to EU labelling regulations.
- Executive summary:
A study was performed to assess the acute dermal toxicity of the test material in the Sprague-Dawley CD strain rat. the method used followed that described in the OECD Guidelines for Testing of Chemicals No. 402 "Acute Dermal Toxicity" (adopted 24 February 1987) and Method B3 of Commission directive 92/69/EEC (which constitutes Annex V of Council Directive 67/548/EEC).
The acute dermal median lethal dose (LD50) of the test material, PX-200, in the Sprague-Dawley CD strain rat was found to be greater than 2000 mg/kg/bw. No symbol and risk phrases are required according to EU labelling regulations.
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