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Physical & Chemical properties

Partition coefficient

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Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
16 March 2021 – 24 March 2021
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient - Shake Flask Method)
Deviations:
no
Remarks:
Although the method described applies only to essentially pure substances soluble in water and n-octanol, it was used to obtain an average partition coefficient of this material which contains a number of different organic & inorganic compounds.
Type of method:
flask method
Partition coefficient type:
octanol-water
Analytical method:
photometric method
Key result
Type:
log Pow
Partition coefficient:
ca. -0.52
Temp.:
20 °C
pH:
ca. 6.98
Details on results:
The Partition Coefficient, log10P of the soluble parts of the sample in octanol and distilled water at 20±2oC was found to be -0.52 ± 0.12. The partition coefficient of the whole sample should be considered indeterminate.
Conclusions:
The Partition Coefficient, log10P of the sample in octanol and distilled water at 20 ± 2 oC was examined by the shake flask method using UV absorption. However, the sample is a mixture of compounds only few of which are soluble, therefore the partition coefficient of the whole sample should be considered indeterminate. Taking into account the soluble parts, the partition coefficient of the substance found to be -0.52 ± 0.12.
Executive summary:

The Partition Coefficient, log10P of the sample in octanol and distilled water at 20 ± 2 oC was examined by the shake flask method using UV absorption. However, the sample is a mixture of compounds only few of which are soluble, therefore the partition coefficient of the whole sample should be considered indeterminate. Taking into account the soluble parts, the partition coefficient of the substance found to be -0.52 ± 0.12.  

Description of key information




EU Method A.8 (Partition Coefficient - Shake Flask Method)  






 


Key value for chemical safety assessment

Additional information

The sample is a mixture of compounds only few of which are soluble. Hence, the partition coefficient of the whole sample should be considered indeterminate.


However, the test was performed to evaluate the solubility of the soluble parts and was found to be -0.52 ± 0.12.