Registration Dossier
Registration Dossier
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EC number: 610-200-5 | CAS number: 446292-07-5
Melting point / freezing point
Administrative data
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- thermal analysis
Test material
- Reference substance name:
- 1H-Isoindole-1,3(2H)-dione, 2-[(2R)-2-hydroxy-3-[[4-(3-oxo-4-morpholinyl)phenyl]amino]propyl]-
- IUPAC Name:
- 1H-Isoindole-1,3(2H)-dione, 2-[(2R)-2-hydroxy-3-[[4-(3-oxo-4-morpholinyl)phenyl]amino]propyl]-
- Reference substance name:
- 2-[(2R)-2-hydroxy-3-{[4-(3-oxomorpholin-4-yl)phenyl]amino}propyl]-1H-isoindole-1,3(2H)-dione
- EC Number:
- 610-200-5
- Cas Number:
- 446292-07-5
- Molecular formula:
- C21 H21 N3 O5
- IUPAC Name:
- 2-[(2R)-2-hydroxy-3-{[4-(3-oxomorpholin-4-yl)phenyl]amino}propyl]-1H-isoindole-1,3(2H)-dione
Constituent 1
Constituent 2
Results and discussion
Melting / freezing pointopen allclose all
- Key result
- Melting / freezing pt.:
- 206.87 °C
- Remarks on result:
- other: pressure not reported; (closed crucible, after recrystallization), mean value out of two measurements
- Key result
- Melting / freezing pt.:
- 208.85 °C
- Remarks on result:
- other: pressure not reported; (open crucible, after recrystallization), mean value out of two measurements
Any other information on results incl. tables
Mean value of these four measurements: 207.9 °C.
Applicant's summary and conclusion
- Conclusions:
- The sample is closed up in a crucible made of aluminium and heated up in a DTA-system (heat ing rate 1 K/min). In comparison with an inert sample the temperature difference and the heat effect is recorded. The melting curve of the sample is a steep endothermic signal. The melting point is determined at 207.9 °C.
- Executive summary:
Hydroxyaminophthalimid has a melting point of 206.13°C, 207.61°C (closed crucible, after recrystallization) and of 208.53°C, 209.17 (open crucible, after recrystallization). Mean value of these four determinations = 207.9°C (Bayer Study,2007). The pressure is not reported.
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