Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Toxicity to reproduction

Currently viewing:

Administrative data

Endpoint:
screening for reproductive / developmental toxicity
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
other: QSAR report
Title:
Unnamed
Year:
2023

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: QSAR prediction
Principles of method if other than guideline:
No guideline specified
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
[bis(4-methylphenyl)phosphoroso](2,4,6-trimethylphenyl)methanone
EC Number:
884-585-5
Cas Number:
270586-78-2
Molecular formula:
C24H25O2P
IUPAC Name:
[bis(4-methylphenyl)phosphoroso](2,4,6-trimethylphenyl)methanone

Results and discussion

Results: P0 (first parental generation)

Effect levels (P0)

Dose descriptor:
NOAEL
Effect level:
57.6 mg/kg bw/day
Remarks on result:
not determinable because of methodological limitations

Target system / organ toxicity (P0)

Critical effects observed:
no

Results: F1 generation

Effect levels (F1)

Dose descriptor:
NOAEL
Effect level:
57.6 mg/kg bw/day
Remarks on result:
not determinable because of methodological limitations

Target system / organ toxicity (F1)

Critical effects observed:
no

Overall reproductive toxicity

Reproductive effects observed:
no

Applicant's summary and conclusion