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EC number: 687-634-7 | CAS number: 231937-89-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- May 5, 2006 - October 14, 2006
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- 2-methyl-4-oxo-3-(prop-2-en-1-yl)cyclopent-2-en-1-yl (1R)-2,2-dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropane-1-carboxylate
- EC Number:
- 687-634-7
- Cas Number:
- 231937-89-6
- Molecular formula:
- C19H26O3
- IUPAC Name:
- 2-methyl-4-oxo-3-(prop-2-en-1-yl)cyclopent-2-en-1-yl (1R)-2,2-dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropane-1-carboxylate
- Test material form:
- liquid: viscous
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Doses:
- 300 and 2000 mg/kg body weight
- No. of animals per sex per dose:
- Set 1 - 3 female , 2000 mg/Kg body weight
Set 2 - 3 female , 300 mg/Kg body weight
Set 3 - 3 female , 300 mg/Kg body weight
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 2 rats at 2000 mg/kg bw
0 rats at 300 mg/kg bw - Clinical signs:
- observations of tremors
- Gross pathology:
- pathological lesions at 2000 mg/kg bw treatment related
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The acute median lethal dose LD50 (cut off value) of d-allethrin in Wistar rats was found to be 1000 mg/kg bw.
- Executive summary:
Rats were dosed with the test material as single dose oral gave. The first set of 3 female rats was given a single dose of 2000 mg/kg bw and 2 rats were found dead the day of dosing. Therefore the second set of 3 female rats was administered with a single dose of 300 mg/kg bw. No mortality was observed at this dose so the third set or 3 female rats was administered with the same dose.
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