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EC number: 424-190-3 | CAS number: 105641-66-5 DIAZO ER 1273
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- July 15, 1992 to October 13, 1992
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- column elution method
- Key result
- Water solubility:
- < 10 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- Details on results:
- Preliminary experiments showed a water solubility of less than 10 mg/L.
As the substance is not stable in solutions under light exposure, the column elution method was performed under light exclusion, as far as possible.
As a result, the test substance does not elute with water. On the other hand the column check with acetonitrile showed a massive difference of 3 mg between applied and found test substance. Regarding poor stability in solution, both results have to be questioned. The water solubility was thus derived from the preliminary experiments. - Conclusions:
- The water solubilty was determined to be <10 mg/L.
- Executive summary:
The water solubility was determined using the column elution method, which was not easy to conduct as it is not possible under complete exclusion from light. Thus, the water solubilty was determined to be <10 mg/L based on preliminary results.
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- October 24, 2019 to February 11,2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- flask method
- Specific details on test material used for the study:
- Storage conditions: Refrigerator (2°C to 8°C)
- Key result
- Water solubility:
- < 0.046 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- Remarks on result:
- other: solubility is below the quantification limit
- Details on results:
- Preliminary test
ln a stepwise procedure, increasing volumes of demineralized water were added at room temperature to a defined amount of the test item. After each addition of an amount of water the mixture was treated with ultrasound for 15 minutes and visually checked for any undissolved particles. Three additional preliminary tests were carried out with specified amounts of the test item and 100 mL and 500 mL demineralized water, respectively. After each addition of an amount of water, the mixture was stirred for at least 24 hours, and visually checked for any undissolved particles. None of the preliminary tests showed a completely solved test item. However, the solutions showed an intensive yellow colouration. The preliminary test showed that the water solubility of the test item was < 10 mg/L. According to the preliminary test the water solubility should have been determined by the column elution method in the main test. However, due to the colouration and the chemical characteristics of the test item value the flask method with two different loading rates was used.
Flask method (1st test series)
Two different loading rates were used (100 mg/L and 1000 mg/L). ln this test series normal glass equipment was used. The development of an analytical method was performed parallel to the flask method. During the development of the methodology it became apparent that the test item solutions were not stable under the influence of daylight. For this reason, this test series was not evaluated.
Flask method (2ndtest series)
Different from the 1st test series brown glass equipment was used to exclude an influence by light. Furthermore, two different loading rates were used (approx. 100 mg/L and 500 mg/L). After the equilibration time precipitate was observed in the flasks of the experiments excluding in the blank experiment.
ln the experiments with a loading rate of 100 mg/L and 500 mg/L the water solubility was below the detection limit of 0.046 mg/L.
The 1st test series was performed with clear glass equipment and the 2nd test series with brown glass equipment in order to protect the test item solutions from light. Furthermore, the standards for the calibration were diluted mixtures of acetonitrile and buffer solution (pH 4) in the 2nd test series. ln the 1st test series, the HPLC investigation of the test item dissolved in mixtures of acetonitrile and water showed several peaks. The HPLC chromatograms of the 2nd test series showed only one peak which could be assigned to the test item. Therefore, the HPLC measurements which were performed within the two test series indicated that the test item decomposes in the presence of light and depending of the pH value. According to the sponsor the intensive yellow colouration observed in the preliminary test is characteristic for the fine-grained test item. The colouration is presumably due to competing effects like slight amounts of very colour-intense impurities (referred to CoA) or dispersed particles in the test item solution or decomposition effects. Due to the instability of the test item it can only be assumed that the water solubility of the test item is below 10 mg/L. - Conclusions:
- The water solubility cs of the test item at a temperature of 20°C was determined according to the flask method. It was found to be below the quantification limit: cs < 0.046 mg/L.
- Executive summary:
The water solubility was determined according to OECD 105 using the flask method. The preliminary test showed that the water solubility of the test item is < 10 mg/L. The column elution method showed a solubility: cs < 0.046 mg/L.
Referenceopen allclose all
Description of key information
The water solubility cs of the test item at a temperature of 20°C was determined according to the flask method and was found to be below the quantification limit, cs < 0.46 mg/L (reference 4.8-1).
Key value for chemical safety assessment
Additional information
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Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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