Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Additional toxicological data

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Administrative data

additional toxicological information
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
supporting study
2 (reliable with restrictions)

Data source

Reference Type:
study report

Materials and methods

Type of study / information:
Type: other: nephrotoxicity
Test guideline
no guideline available
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
most likley 8008-20-6
most likley 8008-20-6
Test material form:
other: low viscosity liquid hydrocarbon

Results and discussion

Applicant's summary and conclusion

Exposure to keosine can cause light hydrocarbon nephropathy in male rats. This male rat specific finding is reagerded as not relevant to human health
Executive summary:

The characteristic nephropathy shown by male rats when exposed to naphtha fractions used in blending gasoline has also been observed with kerosine-type jet fuels. Bruner and Pitts recorded such findings in a 90-day inhalation study with Fischer 344 rats using petroleum-derived jet fuels JP-4 and JP-5 at atmospheric concentrations of 0.15 to 1.0 mg/l. It is accepted that this effect is not relevant for humans.