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Diss Factsheets
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EC number: 606-793-5 | CAS number: 21535-43-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- not specified
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- N-(2-benzylphenyl)-2-chloroacetamide
- EC Number:
- 606-793-5
- Cas Number:
- 21535-43-3
- Molecular formula:
- C15 H14 Cl N O
- IUPAC Name:
- N-(2-benzylphenyl)-2-chloroacetamide
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium, other: TA98 and TA100
- Additional strain / cell type characteristics:
- not specified
Results and discussion
Test results
- Species / strain:
- S. typhimurium, other: TA 98 and TA100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
Applicant's summary and conclusion
- Conclusions:
- Based on the results of this study it is concluded that WAL 801 CHLORACETAMID is not mutagenic in the bacterial reverse mutation assay for Salmonella typhimurium TA 100 and TA 98 with and without S9 metabolic activation.
- Executive summary:
WAL 801 CHLORACETAMID was tested in the Salmonella typhimurium reverse mutation assay with two histidine-requiring strains of Salmonella typhimurium (TA 100 and T A98).
WAL 801 CHLORACET AMI D was tested up to concentrations of 5000 ~g/plate in the absence and the presence of S9-mix. WAL 801 CHLORACETAMID precipitated on the plates at dose level of 1 000 ~g/plate and upwards.
The bacterial background lawn was not reduced at all concentrations tested in both tester strains. In tester strain T A98, an extreme reduction in the number of revertants was observed at the test substance concentration of 5000 ~g/plate both in the absence and presence of S9-mix. In tester strain TA 100, an extreme reduction in the number of revertants was observed at test substance concentrations of 3330 and 5000 ~g/plate both in the absence and presence of S9-mix.
WAL 801 CHLORACETAMID did not induce a dose-related increase in the number of revertant colonies both in the absence and the presence of S9-mix.
Based on the results of this study it is concluded that WAL 801 CHLORACETAMID is not mutagenic in the Salmonella typhimurium reverse mutation assay.
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