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Diss Factsheets
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EC number: 205-538-1 | CAS number: 142-47-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- No data available
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Not a relevant exposure route. Study used as supporting data.
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute Toxicity of Monosodium L-glutamate in Mice and Rats
- Author:
- Hirofumi Moriyuki
- Year:
- 1 978
- Bibliographic source:
- Pharmacometrics, Volume 15, pages 433-436
Materials and methods
- Principles of method if other than guideline:
- No specific guideline followed.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Sodium hydrogen glutamate
- EC Number:
- 205-538-1
- EC Name:
- Sodium hydrogen glutamate
- Cas Number:
- 142-47-2
- Molecular formula:
- C5H8NNaO4
- IUPAC Name:
- sodium hydrogen 2-aminopentanedioate
- Details on test material:
- - Mono sodium glutamate which was commercially available as a food additive was used in this experiment.
- Substance type: hydrated form.
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- ICR
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: No data available
- Age at study initiation: 4 weeks
- Weight at study initiation: 18 to 23 g
- Fasting period before study: not applicable
- Housing: 10 animals per cage
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: no data available
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 23
- Humidity (%): 50
- Air changes (per hr): no data available
- Photoperiod (hrs dark / hrs light): no data available
Administration / exposure
- Route of administration:
- subcutaneous
- Vehicle:
- physiological saline
- Details on exposure:
- MAXIMUM DOSE VOLUME APPLIED: 40 ml/kg
DOSAGE PREPARATION (if unusual): the test substance was given as a physiological saline solution
- Doses:
- 0, 5.50, 6.00, 6.60, 7.26, 8.00, 8.80 and 9.68
- No. of animals per sex per dose:
- 10
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data available
- Necropsy of survivors performed: no
- Other examinations performed: acute toxic of mono sodium glutamate during 2 hours after dosing
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 8.2 other: g/kg
- 95% CL:
- >= 7.66 - <= 8.77
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 8.4 other: g/kg
- 95% CL:
- >= 7.95 - <= 8.88
- Mortality:
- Dosage 5.50 g/kg: female 1/10
Dosage 7.26 g/kg: male 2/10, female 1/10
Dosage 8.00 g/kg: male 4/10, female 2/10
Dosage 8.80 g/kg: male 7/10, female 8/10
Dosage 9.68 g/kg: male 10/10, female 10/10 - Clinical signs:
- Acute toxic of mono sodium glutamate during 2 hours after dosing:
Dosage 4.30-6.00 g/kg: abdominal posture, palpebral closure, sedation, ataxia, twich, cyanosis
Dosage 6.12-9.68 g/kg: vocalization, stagering gait, excitation, spasm of limbs, jumping, tail elevation, tonic convulsion, death - Body weight:
- Mice which escaped from acute death showed no apparent change in body weight gains at one and two weeks after dosing
- Gross pathology:
- No significant abnormalities were observed in the gross findings of the visceral organs at the termination of the study.
Applicant's summary and conclusion
- Conclusions:
- LD50 values (g/kg body weight) by subcutaneous route represented by male and female mice were 8.20 and 8.40.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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