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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 256-360-6 | CAS number: 48145-04-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 12 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 25
- Dose descriptor starting point:
- NOAEL
- Value:
- 350 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 309 mg/m³
- Explanation for the modification of the dose descriptor starting point:
No inhalation study available. Thus, extrapolation from 90D oral study wtih a NOAEL of 350 mg/kg bw/d with respect to repeated dose toxicity.
Using this value as a starting point for chronic DNEL derivation for workers with respect to dermal and inhalational exposure:
DNEL, inhalation, workers:
Adjustment of dose metric to inhalational concentration:
The REACH R.8 guidance uses an inhalation volume for rats of 0.38 m3/kg for 8 hr exposure
Thus NOAEL to NOAEC conversion:
NOAEC rats = 350 mg/kg/d / 0.38 m3/kg = 921 mg/m3
As no data is available for absorption rate for oral exposure versus inhalation exposure a default factor of 2 is used for accounting for the potential for higher absorption by inhalation :
NOAEC rats = 921 mg/m3 / 2 = 461 mg/m3
Correction factor for increased inhalation volume during work:
NOAEC worker, 8hr = 6.7 m3/ 10m3 x 461 mg/m3 = 309 mg/m3
- AF for dose response relationship:
- 1
- Justification:
- default
- AF for differences in duration of exposure:
- 2
- Justification:
- Extrapolation from 90 D study to chronic exposure situation
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- not used when dose metric is already concerted to mg/m3
- AF for other interspecies differences:
- 2.5
- Justification:
- default
- AF for intraspecies differences:
- 5
- Justification:
- default
- AF for the quality of the whole database:
- 1
- Justification:
- default
- AF for remaining uncertainties:
- 1
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 77 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- DNEL derivation method:
- other: SCOEL OEL value on acrylic acid as indicative DNEL value for 2-phenoxyethyl acrylate.
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 3.5 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 100
- Dose descriptor starting point:
- NOAEL
- Value:
- 350 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- No dermal repeated dose studies available. Absorption by dermal route is by default considered identical to absorption from oral route.
- AF for dose response relationship:
- 1
- AF for differences in duration of exposure:
- 2
- Justification:
- extrapolation from 90D study to chronic exposure situation
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- default
- AF for other interspecies differences:
- 2.5
- Justification:
- default
- AF for intraspecies differences:
- 5
- Justification:
- default
- AF for the quality of the whole database:
- 1
- AF for remaining uncertainties:
- 1
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
- Most sensitive endpoint:
- acute toxicity
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- high hazard (no threshold derived)
- Most sensitive endpoint:
- sensitisation (skin)
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
2-phenoxyethyl acrylate has low acute toxicity (oral and dermal). No data for the acute inhalational toxicity is available. Results from irritation studies (skin and eye) indicates a no to low potential. The substance has been shown to be a sensitizer in a Guinea pig maximisation test and should therefore accordingly be classified as Skin. Sens. 1A. Based on the data from an OECD 422 study (conducted in 2012/2013), a NOAEL of 300 mg/kg bw/day for systemic repeated dose toxicity is concluded. Further, a NOAEL of 800 mg/kg bw/day (male) and 300 mg/kg bw/day (female, based on post implantation losses) for reproductive toxicity was concluded.
Exposure of 2-phenoxyethyl acrylate to humans is only relevant for workers in industrial processing and professional uses. Based on the physical/chemical properties, dermal absorption is considered the most relevant exposure route. DNEL for systemic effect of 3.5 mg/kg bw/day has been derived based on a NOAEL of 350 mg/kg bw/day for sytemoc effects in relation to repeated dose toxicity in a OECD 408 study (90D oral exposure). This DNEL value is considered conservative as dermal absorption is considered equal to oral absorption. No DNEL for skin sensitising effects can be derived, thus dermal exposure is considered most critical route of exposure.
Based on the NOAEL of 350 mg/kg/bw /day from oral exposure, a DNEL for inhalation of 12 mg/m3 was derived by route-to-route extrapolation for protection against any systemic effects.
As hydrolysis of 2-phenoxyethyl acrylate into acrylic acid and 2-phenoxyethanol may occur, there is a potential of local toxicity in the lung due to the formation of acrylic acid. In 2012, SCOEL derived an OEL value of 10 ppm (29 mg/m3) for acrylic acid. 10 ppm of 2 -phenoxyethyl acrylate equivalates to 77 mg/m3. This worst case and indicative DNEL value for local effects is less restrictive than the DNEL for systemic effects (10 mg/m3).
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
Exposure of consumers/general population to 2-phenoxyethyl acrylate is not relevant as only used in industrial settings and professional uses. Therefore, no hazard identification for consumers/general population considered necessary.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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