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EC number: 218-747-8 | CAS number: 2224-33-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 08 Oct 2007 - 25 Jan 2008
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- The study was conducted according to an appropriate OECD test guideline, and in compliance with GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 425 (Acute Oral Toxicity: Up-and-Down Procedure)
- Version / remarks:
- adopted 2001
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- up-and-down procedure
- Limit test:
- no
Test material
- Reference substance name:
- Butan-2-one O,O',O''-(vinylsilylidyne)trioxime
- EC Number:
- 218-747-8
- EC Name:
- Butan-2-one O,O',O''-(vinylsilylidyne)trioxime
- Cas Number:
- 2224-33-1
- Molecular formula:
- C14H27N3O3Si
- IUPAC Name:
- N-[Bis[[(E)-butan-2-ylideneamino]oxy]-ethenylsilyl]oxybutan-2-imine
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report): O,O',O''-(ethenylsilylidyne)trioxime 2-butanone
- Substance type: Ketoxime
- Physical state: Liquid
- Stability under test conditions: Stable in sealed containers
- Storage condition of test material: Stored in sealed containers, may be sensitive to moisture
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Labs, Shaver Road, Portage, MI, USA
- Age at study initiation: 8 wk
- Weight at study initiation: 206-284 g
- Fasting period before study: overnight
- Housing: 1/suspended wire mesh cage
- Diet: LabDiet 5002, Certified Rodent Diet (PMI nutrition International), ad libitum
- Water: drinking water, ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20.95-23.63
- Humidity (%): 43-58
- Air changes (per hr): 12.5
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 2007-10-8 To: 2007-10-29
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: < 10 ml/kg bw
- Rationale for the selection of the starting dose: lower than LD50 for closely related material - Doses:
- 550, 2000 mg/kg bw
- No. of animals per sex per dose:
- 550 mg/kg bw: 1 male; 2000 mg/kg bw: 3 males
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: mortality/viability: twice daily (once daily on weekends and holidays); weight: prior to dosing and weekly thereafter
- Necropsy of survivors performed: yes
- Clinical observations: 20-40 min after dosing, 3-4 h after dosing, and daily thereafter - Statistics:
- none applied for determination of LD50
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No deaths.
- Mortality:
- none
- Clinical signs:
- other: 2000 mg/kg bw: Two of three rats showed transient adverse effects including absence of or decreased activity, increased lacrimation, partially closed eye lids bilaterally, irregular respiration, red soiling of the muzzle or urogenital staining. These effe
- Gross pathology:
- One animal at 2000 mg/kg bw had a small focus on the left lateral liver lobe.
- Other findings:
- None.
Any other information on results incl. tables
One male rat was given a single dose of 550 mg/kg bw of the test substance by oral gavage. The animal showed no adverse effects within 3 days of dosing and appeared healthy. A second fastened male was dosed with 2000 mg/kg bw and also showed no adverse effects within 3 days of dosing and appeared healthy. A third male rat was dosed with 2000 mg/kg bw and showed adverse effects which were fully reversible within 3 days. Another rat was dosed with 2000 mg/kg bw and also showed adverse effects, which were reversible within 3 days.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified (CLP Regulation EC no. 1272/2008)
- Conclusions:
- A reliable acute oral toxicity study conducted in compliance with a standard guideline and GLP (reliability score 1), identified an LD50 in excess of 2000 mg/kg bw in male rats.
- Executive summary:
An acute oral toxicity test was performed according to OECD 425 and GLP on butan-2-one O,O',O''-(vinylsilanetriyl)oxime. No mortality was observed and the LD50 was determined to be >2000 mg/kg bw in rats.Two of three rats showed transient adverse clinical signs which were no longer evident on day 3.
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