Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 223-989-2 | CAS number: 4156-21-2
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The NOEC of the test item Active Substance of Granofin Easy F-90 liq in Aqueous Solution is 320 mg a.i./L. The test item is not toxic up to the concentration of 320 mg a.i./L to activated sludge of a municipal sewage treatment plant. The EC20 of the test item is 554 mg a.i./L and the EC50 is > 1000 mg a.i./L.
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 320 mg/L
Additional information
A Respiration Inhibition Test with activated sludge according to OECD Guideline No. 209 was carried out with the test item Active Substance of Granofin Easy F-90 liq in aqueous solution (batch number:ITA0056831)from 2012-05-23 to 2012-05-24, with the definitive experimental phase on 2012-05-24, at theDr.U.Noack-Laboratorien, D-31157Sarstedt.Test system was activated sludge of the municipal treatment plant of D-31137 Hildesheim. The test was carried out under static conditions with the substance concentrations 100 - 180 - 320 - 580 - 1000 mg a.i./L, corresponding to 145 - 261 - 464 - 840 - 1449 mg/L. The respiration rates of the control, reference and test item replicates were measured after a contact time of three hours, and the inhibitory effects of the test and reference item were determined in comparison to the control respiration rates. The mean inhibition of respiration for the test item replicates ranged from -10 % to 41 %.
In order to check the activity of the test system and the test conditions a reference test was carried out with copper (II) sulphate pentahydrate as reference item and the reference toxicity was determined. The EC50-value for the reference item was 88.7 mg/L.
EC-Values with Confidence Interval of Active Substanceof Granofin Easy F-90 liq in aqueous solution
EC-values |
Confidence interval |
|
NOEC* |
320 |
– |
EC20 |
554 |
516 - 593 |
EC50 |
> 1000 |
– |
EC80 |
> 1000 |
– |
The NOEC of the test itemActive Substanceof Granofin Easy F-90 liq in Aqueous Solution is320 mg a.i./L.
The test item is not toxic up to the concentration of320mg a.i./L to activated sludge of a municipal sewage treatment plant. The EC50of the test item is> 1000 mg a.i./L.
In a second Respiration Inhibition Test with activated sludge according to OECD 209 it was shown, that the test item is not toxic up to the highest tested concentration (IC50 > 100 mg/L). This supports the results from the kew study.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
