Registration Dossier
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Diss Factsheets
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EC number: 229-222-8 | CAS number: 6440-58-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Additional information
Several reliable (Klimisch 1 or 2) toxicity studies in fish, invertebrates, and algae have been conducted using DMDMH or the hydrolysis product of DMDMH (DMH) and are included in this dossier. DMDMH readily undergoes hydrolysis to DMH and therefore data is provided for both substances where available. In the case of long-term testing, the data on DMH is considered more relevant for environmental fate and ecotoxicology and are considered in this dossier. These Key studies are summarized below. There were no reliable toxicity data for aquatic plants; however, a waiver is being applied for this endpoint.
Adequate reliable measured data exists for short-term toxicity to fish exposed to the test substance DMDMH within this dossier. The most sensitive reliable study result has been identified as a study (Ciliutti 2003) which reports an LC50 for short-term toxicity in fish of >82.3 mg/L. Consequently this value will be taken as the short-term toxicity in fish endpoint for DMDMH.
No reliable (Klimisch 1 or 2) long-term toxicity studies with fish have been conducted for DMDMH, although a reliable (Klimisch 1) long-term toxicity study with fish using DMH is included in this dossier. The study (Holmes & Swigert 1993) provides an estimated NOEC of 14 mg/L based on growth. Consequently this value will be taken as the long-term toxicity in fish endpoint for DMDMH.
Reliable (Klimisch 1 or 2) short-term toxicity studies with invertebrates have been conducted for DMDMH and its hydrolysis products and are included in this dossier. As a conservative approach, the most sensitive result across these substances has been taken as the endpoint for DMDMH. The key study, Ciliutti (2003), provides a 48-hr EC50 of 29.1 mg/L for Daphnia magna. Consequently this value will be taken as the short-term toxicity in aquatic invertebrate endpoint for DMDMH.
No reliable (Klimisch 1 or 2) long-term toxicity studies with invertebrates have been conducted for DMDMH, although a reliable (Klimisch 1) long-term toxicity study with invertebrates using DMH is included in this dossier. The study (Zelinka et al., 1993) provides an estimated NOEC of 70.9 mg/L based on reproduction and mortality. Consequently this value will be taken as the long-term toxicity in invertebrates endpoint for DMDMH.
Reliable (Klimisch 1) toxicity studies with algae have been conducted for DMDMH and DMH, the hydrolysis product of DMDMH and are included in this dossier. The study Vryenhoef & Mullee (2007) provides an estimated 72hr EC50 of 11 mg/L and 72hr NOEC of 5.1 mg/L, based on growth using DMDMH. Consequently this value will be taken as the toxicity in algae endpoint for DMDMH.
Reliable (Klimisch 1) toxicity studies with microorganisms have been conducted for DMDMH and DMH, the hydrolysis product of DMDMH and are included in this dossier. The study Ciliutti (2003) provides an estimated 72hr EC50 of >100 mg/L and the NOEC was 100 mg/L based on growth using DMDMH. Consequently this value will be taken as the toxicity in microorganisms endpoint for DMDMH.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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