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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Link to relevant study record(s)

Description of key information

Key value for chemical safety assessment

Additional information

No experimental data on toxicokinetics, metabolism and distribution is available for 2-hexyldecan-1-ol or any other structural analogue of the Guerbet alcohol category. Based on the physical-chemical properties of Guerbet alcohols and the available toxicity data the following assumptions can be made.

2-Hexyldecan-1-ol has a very low water solubility below 1 mg/l. Therefore the dissolution of the substance is regarded as the rate limiting step for the absorption process from gastrointestinal tract. Amounts of the substance which were absorbed are distributed within the organism by systemic circulation. Due to its lipophilic properties (log Pow > 6) absorbed 2-hexyldecan-1-ol can bind to plasma proteins and a theoretical bioaccumulation in fat tissue cannot totally be excluded, nevertheless the substance is expected to be extensively metabolised.

As first step of the biotransformation of resorbed 2-hexyldecan-1-ol mainly the oxidation of the alcohol to the corresponding carboxylic acid by phase I enzymes is expected. The carboxylic acid is then expected to be glucoronised by the phase II enzymes UDP-glucuronosyltransferases to the ester glucuronides and excreted. Only minor parts of 2-hexyldecan-1-ol are expected to be metabolized and excreted as alcohol glucuronides.

This described metabolism is highly efficient and 2-hexyldecan-1-ol is therefore not expected to have a tissue retention or bioaccumulation potential. This is supported by the available oral sub-chronic toxicity study of the structural analogue 2-octyldodecan-1-ol which shows no substance-dependent toxic effects at doses of 1000 mg/kg bw/d.