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EC number: 276-017-4 | CAS number: 71786-67-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1999
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Qualifier:
- according to guideline
- Guideline:
- ISO 6341 (Water quality - Determination of the Inhibition of the Mobility of Daphnia magna Straus (Cladocera, Crustacea))
- GLP compliance:
- yes
Test material
- Reference substance name:
- Benzyl(3-hydroxyphenacyl)methylammonium chloride
- EC Number:
- 276-017-4
- EC Name:
- Benzyl(3-hydroxyphenacyl)methylammonium chloride
- Cas Number:
- 71786-67-9
- Molecular formula:
- C16H17NO2.ClH
- IUPAC Name:
- benzyl(3-hydroxyphenacyl)methylammonium chloride
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): Benzyladrianon HCl
- Physical state: solid
- Analytical purity: 99.07 %
- Stability under test conditions: stable
- Storage condition of test material: At room temperature in the dark
Constituent 1
Sampling and analysis
- Analytical monitoring:
- not specified
Test organisms
- Test organisms (species):
- Daphnia magna
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- 250 mg/L
- Test temperature:
- 18 - 22 C°
- pH:
- 8.8 - 8.2
- Nominal and measured concentrations:
- At the start the measured concentrations were in agremment or just below nominal concentrations ( 87 % - 94 % ).
During the 24-hour period between renewal the concentrations measured remain within 80 % of the initially measured concentration ( 78 % - 84 % of
nominal ).
The concentrations measured in the freshly prepared solution at 24 hours of exposure showed that the procedure of preparation was repeatable
( 98 % -95 % of nominal ). - Details on test conditions:
- TEST SYSTEM
- Test vessel: 100 mL , all-glass , filling 80 mL
- Aeration: No aeration of test vesssel
- No. of organisms per vessel: 10
- No. of vessels per concentration : 2 - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 45 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 19 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 10 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- - Mortality of control: 0
- Results with reference substance (positive control):
- - Results with reference substance valid? The acutal response in this reference test with potassium dichromate are within the ranges of the expected responses at the different concentrations. Hence, the sensitivity of this batch of D.magna was in agreement with the historical data collected at NOTOX
- 24 h EC50 > 1.8 mg/L
- 48 h EC50 = 0.95 mg/L
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Under the conditions of the present study Benzyladrianon HCl did not induce acute immobilisation of Daphnia magna at 10 mg/L after 48 hours of
exposure.
The 24h-EC50 was 45 mg/L based on nominal exposure concentrations ( 95 % confidence interval between 42 and 50 mg/L).
The 48h-EC50 was 19 mg/L based on nominal exposure concentrations ( 95 % confidence interval between 17 and 22 mg/L) . - Executive summary:
Acute Toxicity Studey with Daphnia magna with Benzyladrianon HCl.
After a static range-finding test, a final EC50 test was performed with Daphnia magna exposed for a maximum of 48 hours to range of nominal concentrations from 10 to 100 mg/L. The test was performed under semi-static conditions with renewal of the test solution after 24 hours of exposure. The test was performed in duplicate with 10 daphnia per vessel. Samples were taken from the freshly prepared solutions at the start and the 24 hour old and from the freshly prepared solutions after 24 hour exposure.
At the start the measured concentrations were in agreement or just below nominal concentrations ( 87 % - 94 % ).
During the 24-hour period between renewal the concentrations measured remain within 80 % of the initially measured concentration
( 78 % - 84 % of nominal ).The concentrations measured in the freshly prepared solution at 24 hours of exposure showed that the procedure of preparation was repeatable ( 98 % -95 % of nominal ). Hence, the procedure of preparation was repeatble and toxicity parameters were based on the nominal concentartions.
Under the conditions of the present study Benzyladrianon HCl did not induce acute immobilisation of Daphnia magna at 10 mg/L after 48 hours of exposure. The 24h-EC50 was 45 mg/L based on nominal exposure concentrations ( 95 % confidence interval between 42 and 50 mg/L). The 48h-EC50 was 19 mg/L based on nominal exposure concentrations ( 95 % confidence interval between 17 and 22 mg/L).
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