Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 445-910-2 | CAS number: 1388152-30-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_environmental-fate-and-pathways.png)
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 28-May 2003-28 June 2003
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study was conducted in 2003 according to OECD Method # 301B and EU method C.4-C and in accordance with GLP. The study material is well characterized.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-C (Determination of the "Ready" Biodegradability - Carbon Dioxide Evolution Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 445-910-2
- EC Name:
- -
- Cas Number:
- 1388152-30-4
- Molecular formula:
- Hill formula: C24 H32 N2 O7 Si CAS formula: C15 H20 O3 Si . C9 H12 N2 O4
- IUPAC Name:
- (1R,2R)-1,3-Dihydroxy-1-(4-nitrophenyl)propyl-2-ammonium (1R, 5S)-5-(dimethylphenylsilyl)-2-(hydroxymethyl)cyclopent-2-ene-1-carboxylate
- Details on test material:
- Buff coloured powder; stored at room temperature in the dark; received at testing laboratory on 22 April 2003. Test material was dissolved directly in culture medium. Final concentration in the test vessel was 16.1 mg/L equivalent to 10mg carbon/L.
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
Standard material used was sodium benzoate dissolved in culture medium with a final concentration in the test vessel of 16.1 mg/L equivalent to 10 mg carbon per liter.
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- Upon receipt sample of activated sludge is maintained on continuous aeration. Excessive amounts of dissolved organic carbon are removed from the activated sewage sludge sample by washing 3 times by settlement and resuspension in culture medium. The suspended solids level of the sludge was determined to be 3.2 g/L prior to use.
- Duration of test (contact time):
- 0 - 28 d
Initial test substance concentration
- Initial conc.:
- 10 mg/L
- Based on:
- other: test material (48.3 g) used to equal 10 mg carbon per liter
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- The test material at a concentration of 10 mg carbon per liter was exposed to activated sewage sludge micro-organisms with culture medium in sealed culture vessels in the dark at 21 C for 28 days. The degradation of the test material was assessed by determination of carbon dioxide produced. The following test and control solutions were prepared in duplicate and inoculated into 5 liter glass vessels each contained 3 liters solution; 1) inoculated culture medium ( control), 2). the standard material (sodium benzoate) in inoculated culture medium at a final concentration of 10 mg carbon /liter 3) the test material in inoculated culture medium at a final concentration of 10 mg carbon /liter and 4) test material plus standard material in inoculated culture medium at a final concentration of 20 mg carbon/L to act as a toxicity control. The culture vessels are sealed and CO2 free air bubbled through the solution at 40 ml/minute. CO2 produced by the degradation is collected in two 500mL bottles containing 350 ml of 0.05M sodium hydroxide as absorbing solution
Reference substance
- Reference substance:
- other: Sodium benzoate
Results and discussion
- Test performance:
- The test validation criteria were acceptable for total CO2 evolution in control vessels, the IC/TC ratio at the start , the test material 's (sodium benzoate) degradation % and the difference in CO2 production at the end of the test for the replicate vessels. The toxicity control attained 56% and was considered not toxic to sewage sludge and no carry over was noted in the second absorber vessel. The pH values ranged from 7.3 to 7.5 and the observations throughout the test period showed the contents of vessels for test material, control, standard material and toxicity control to be "light brown dispersions with no undissolved material present". For inorganic carbon analysis on day 29 there was an increases in all but 2 replicate vessels due to the CO2 in solution being driven off upon addition of the hydrochloric acid on day 28 and resulted in slight increases in percentage degradation value from day 28 to day 29.
% Degradationopen allclose all
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 2
- Sampling time:
- 2 d
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 10
- Sampling time:
- 13 d
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 19
- Sampling time:
- 21 d
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 30
- Sampling time:
- 28 d
BOD5 / COD results
- Results with reference substance:
- Points of degradation plot (reference substance):
51 % degradation after 2 d
64 % degradation after 13 d
76 % degradation after 21 d
78 % degradation after 28 d
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- other: not readily biodegradable
- Conclusions:
- The test material attained 30% degradation after 28 days and therefore cannot be considered readily biodegradable under the strict terms and conditions of OECD Guideline No 301B.
- Executive summary:
The test material attained 30% degradation after 28 days and therefore cannot be considered readily biodegradable under the strict terms and conditions of OECD Guideline No 301B. This study was assigned reliability rating of 1 (reliable without restriction) and the results are considered valid.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)