Registration Dossier
Registration Dossier
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EC number: 224-207-2 | CAS number: 4246-51-9
Endpoint summary
Administrative data
Description of key information
Skin sensitizing cat. 1 (QSAR predicition for skin sensitization: weak sensitizer, reliability 2)
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
Since the test substance is corrosive to skin, a sensitisation study does not need to be conducted in accordance with column 2 of REACH Annex VII. However, QSAR modelling with OASIS Times (v. 21.26, Skin sensitization with autoxidation) predicit a weak sensitizing potential after metabilization. Thus, the substance is classified as skin sensitizing Cat. 1.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
There are no human data available indicating a respiratory sensitisation potential.
Justification for classification or non-classification
In accordance with column 2 of REACH Annex VII, a sensitisation study does not need to be conducted. However, based on the available QSAR prediction (OASIS Times, reliability 2), the test substance is considered to be classified as a skin sensitizer Cat. 1 under Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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