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EC number: 243-053-7 | CAS number: 19430-93-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Additional information
Acute toxicity studies on fish, daphnia and algae to protocols equivalent or similar to OECD Guideline studies were conducted to GLP standards on PFBE (3,3,4,4,5,5,6,6,6-nonafluorohexene).
Fish
The objective of the study was the assessment of the acute toxicity of PFBE (3,3,4,4,5,5,6,6,6-nonafluorohexene) on the zebra fish, Danio rerio. Due to the low water solubility and high volatility of the test substance, the study was performed using water accommodated fractions (WAF) of PFBE as the test medium, as recommended for ecotoxicological testing of petroleum products by CONCAWE 1992 and for aquatic toxicity testing of lubricants by ASTM (standard protocol 06081-97). These protocols are designed to comply with the general principles outlined in the respective OECD guidelines.
The acute mortality of zebra fish under semi-static conditions was assessed after 24, 48, 72 and 96 hours. The validity criteria of the OECD Test Guideline 203 were fulfilled under the conditions of the modified procedures.
A concentration-effect relationship could not be established. The highest loading rate of 1000 mg/L PFBE (3,3,4,4,5,5,6,6,6-nonafluorohexene) revealed no toxicity different from controls.
Therefore, in the acute toxicity test with Danio redo (zebra fish), the effect values are as follows:
NOEC >/= 1000 mg/L (loading rate)
LOEC >/= 1000 mg/L (loading rate)
EC 50 > 1000 mg/L (loading rate)
NOEC >/= 1.86 mg/L (measured concentration)
LOEC > 1.86 mg/L (measured concentration)
EC 50 > 1.86 mg/L (measured concentration)
Daphnia
The study was performed to evaluate the effects of PFBE (3,3,4,4,5,5,6,6,6-nonafluorohexene) on the mobility of the freshwater crustacean, Daphnia magna, after a exposure times of 24 and 48 h. The objective of the study was the assessment of the acute toxicity of PFBE to Daphnia magna. Due to the low water solubility and high volatility of the test substance, the study was performed using water accommodated fractions (WAF) of PFBE as the test medium, as recommended for ecotoxicological testing of petroleum products by CONCAWE 1992 and for aquatic toxicity testing of lubricants by ASTM (standard protocol 06081-97). These protocols are designed to comply with the general principles outlined in the respective OECD guidelines. The mobility of the freshwater crustacean, Daphnia magna, under static conditions was assessed after 24 and 48 hours. The validity criteria of the OECD Test Guideline 202 are fulfilled under the conditions of the modified procedures.
Summary of the test results
Up to the highest nominal loading rate of 1000 mg/l no signifcant immobilisation was observed after 24 h and 48 h compared to controls.
NOEC >/=1000 mg/L (loading rate)
LOEC > 1000 mg/L (loading rate)
EC50 > 1000mg/L (loading rate)
NOEC >/= 1.0 mg/L (measured concentration)
LOEC > 1.0 mg/L (measured concentration)
EC50 > 1.0 mg/L (measured concentration)
Algae
The objective of the study was the assessment of the acute toxicity of PFBE on the green alga, Selenastrum capricornutum. Due to the low water solubility and high volatility of the test substance, the study was performed using water accommodated fractions (WAF) of PFBE as the test medium, as recommended for ecotoxicological testing of petroleum products by CONCAWE 1992 and for aquatic toxicity testing of lubricants by ASTM (standard protocol 06081-97). These protocols are designed to comply with the general principles outlined in the respective OECD guidelines.
The growth of the algae under static conditions was assessed after 24, 48, and 72 hours. The validity criteria of the OECD Test Guideline 201 are fulfilled under the conditions of the modified procedures.
Summary of the Algae test results
Inhibition of growth
Up to the highest nominal loading rate of 1000 mg/L PFBE (3,3,4,4,5,5,6,6,6-nonafluorohexene), no significant inhibition of growth (biomass) and growth rate was observed after 72 h compared to controls.
NOEC >/= 1000 mg/L (loading rate)
LOEC > 1000 mg/L (loading rate )
EC50 > 1000 mg/L (loading rate)
NOEC >/= 1.52 mg/L (lmeasured conc)
LOEC > 1.52 mg/L (measured conc )
EC50 > 1.52 mg/L (measured conc)
Promotion of growth
A promotion of growth (biomass) of 36.5 % was observed at the highest loading rate of 1000 mg/L after 72 h.
Conclusion of aquatic toxicity testing
No toxic effects were seen in fish, daphnia and algea in acute aquatic toxicity tests on PFBE (3,3,4,4,5,5,6,6,6-nonafluorohexene)
up to the maximum loading rate of 1000mg/L.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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