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Diss Factsheets
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EC number: 218-491-7 | CAS number: 2163-00-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
1,6-Dichlorohexane is classified as not readily biodegradable in the 10-d-window and after 61 days according to OECD guideline no. 310.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
In the key study, 1,6-dichlorohexane was tested in a 61 d biodegradation study (2012 -0242 -DGO) according to OECD guideline no. 310.The ready biodegradability of the test item 1,6-dichlorohexane was determined with a non adapted activated sludge over a test period of 61 days in the Headspace Test. The test item was tested at a concentration of 30 mg/L in triplicates (test end: 5 replicates), corresponding to a carbon content of 13.4 mg C/L. The biodegradation of the test item was followed by TIC analyses of the quantity of CO2 produced by the respiration of bacteria. The amount of TIC produced was calculated by correcting the results of the test and reference item for endogenous TIC production of the control groups and the blind value of the sodium hydroxide solution.
The test item replicates reached the 10 % level after a long lasting adaptation phase on day 31 and the biodegradation came to 54 % after 61 days. The 95 % confidence interval on day 61 was 49 - 60 %.The test item is classified as not readily biodegradable in the 10 -d-window and after 61 days.
In the first supporting study, 1,6-dichlorohexane was tested in a 7d biodegration study (BASF AG.OECD301F.1980) according to OECD guideline 301 F. In this study the test item showed the degradation of 0% (TOC removal) after 7 days.
Four further non-standard studies showed also only low degradation:
In the second supporting study (Janssen et al_1987), the substrate concentration was decreased to < 0.0005 mM (initial concentration: 0.2 mM) after 6 days.
In a further study (Omori and Alexander_1978), Pseudomonas sp. grew on and resting cells dehalogenated 1,6-dichlorohexane. Chloride release: 6 µg/mL per 48 h.
In two further studies (Heath et al_2004; Heath et al_2006), up to 5 % of chlorine was removed from 1,6-dichlorohexane.
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