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Diss Factsheets
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EC number: 249-060-1 | CAS number: 28510-23-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- other:
- Endpoint:
- hydrolysis
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Validated QSAR model
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Principles of method if other than guideline:
- Calculation based on HYDROWIN v2.00, Estimation Programs Interface Suite™ for Microsoft® Windows v 4.10. US EPA, United States Environmental Protection Agency, Washington, DC, USA.
- GLP compliance:
- no
- Estimation method (if used):
- - Total Kb for pH > 8: 1.084E-003 L/mol sec - Temperature for which rate constant was calculated: 25 °C- Computer programme: HYDROWIN v2.00
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- 202.56 yr
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 8
- Temp.:
- 25 °C
- DT50:
- 20.26 yr
- Type:
- (pseudo-)first order (= half-life)
- Details on results:
- For detailed description on the model and its applicability, see "Any other information on materials and methods incl. tables".
- Validity criteria fulfilled:
- yes
- Conclusions:
- DT50 202.56 years at 25°C, pH 7 DT50 20.26 years at 25°C, pH 8
- Executive summary:
An assessment was conducted on 3-[(2-ethylhexanoyl)oxy]-2,2-dimethylpropyl 2-ethylheptanoate CAS: 28510-23-8 (uncharged) to determine its hydrolysis rate constant. The assessment was done so using the QSAR model Aqueous Hydrolysis Rate Program (HYDROWIN).
Dissipation half-life of parent compound DT50 was determined to be:
DT50 202.56 years at 25°C, pH 7
DT50 20.26 years at 25°C, pH 8
Referenceopen allclose all
Result refers to the uncharged molecule.
Description of key information
Abiotic degradation is not relevant.
Key value for chemical safety assessment
Additional information
Testing is technically not possible. In accordance with Annex VIII, Column 2 (9.2.2.1) of Regulation (EC) No. 1907/2006, testing for hydrolysis as a function of pH is not required since the substance is highly insoluble in water (< 0.01 mg/L in aqua dest). In addition, a QSAR calculation with 2,2-dimethylpropane-1,3-diyl 2-ethylhexanoate (CAS No. 28510-23-8) using HYDROWIN v2.00, indicates that hydrolysis is not a relevant degradation pathway at environmental conditions (DT50 [pH7] > 1 yr; Hopp, 2011).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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