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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Year:
1993
Report date:
1993

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
β-methyl-3-(1-methylethyl)benzenepropanal
EC Number:
412-050-4
EC Name:
β-methyl-3-(1-methylethyl)benzenepropanal
Cas Number:
125109-85-5
Molecular formula:
C13H18O
IUPAC Name:
3-[3-(propan-2-yl)phenyl]butanal

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White

Test system

Vehicle:
not specified
Amount / concentration applied:
.1 ml
Number of animals or in vitro replicates:
3

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
conjunctivae score
Remarks:
(redness)
Basis:
animal #1
Remarks:
(mean score 1)
Time point:
other: overall at 24, 48 and 72 h
Score:
0.25
Max. score:
0.25
Reversibility:
fully reversible within: 1
Irritation parameter:
conjunctivae score
Remarks:
(redness)
Basis:
animal #2
Remarks:
(mean score 2)
Time point:
other: overall at 24, 48 and 72 h
Score:
0.25
Max. score:
0.25
Reversibility:
fully reversible within: 1
Irritation parameter:
conjunctivae score
Remarks:
(redness)
Basis:
animal #3
Remarks:
(mean score 3)
Time point:
other: overall at 24, 48 and 72 h
Score:
0.25
Max. score:
0.25
Reversibility:
fully reversible within: 1
Irritation parameter:
conjunctivae score
Remarks:
(redness)
Basis:
other: max score
Time point:
other: overall
Score:
1
Max. score:
1
Remarks on result:
other: Max. duration: 24 h; Max. value at end of observation period: 0(related to all animals)
Irritation parameter:
chemosis score
Basis:
animal #1
Remarks:
(mean score 1)
Time point:
other: overall at 24, 48 and 72 h
Score:
0.25
Max. score:
0.25
Reversibility:
fully reversible within: 1
Irritation parameter:
chemosis score
Basis:
animal #1
Remarks:
(means score 2)
Time point:
other: overall at 24, 48 and 72 h
Score:
0
Max. score:
0
Reversibility:
fully reversible within: 1
Irritation parameter:
chemosis score
Basis:
animal #3
Remarks:
(mean score 3)
Time point:
other: overall at 24, 48 and 72 h
Score:
0
Max. score:
0
Reversibility:
fully reversible within: 1
Irritation parameter:
chemosis score
Basis:
other: max score
Time point:
other: overall
Score:
1
Max. score:
1
Remarks on result:
other: Max. duration: 24 h; Max. value at end of observation period: 0(related to all animals)
Irritation parameter:
cornea opacity score
Basis:
animal #1
Remarks:
(mean score 1)
Time point:
other: overall at 24, 48 and 72 h
Score:
0
Max. score:
0
Reversibility:
fully reversible within: 1
Irritation parameter:
cornea opacity score
Basis:
animal #2
Remarks:
(mean score 2)
Time point:
other: overall at 24, 48 and 72 h
Score:
0
Max. score:
0
Reversibility:
fully reversible within: 1
Irritation parameter:
cornea opacity score
Basis:
animal #3
Remarks:
(mean score 3)
Time point:
other: overall at 24, 48 and 72 h
Score:
0
Max. score:
0
Reversibility:
fully reversible within: 1
Irritation parameter:
cornea opacity score
Basis:
other: max score
Time point:
other: overall
Score:
0
Max. score:
0
Remarks on result:
other: Max. duration: 72 h; Max. value at end of observation period: 0(related to all animals)
Irritation parameter:
iris score
Basis:
animal #1
Remarks:
(mean score 1)
Time point:
other: overall at 24, 48 and 72 h
Score:
0
Max. score:
0
Reversibility:
fully reversible within: 1
Irritation parameter:
iris score
Basis:
animal #2
Remarks:
(mean score 2)
Time point:
other: overall at 24, 48 and 72 h
Score:
0
Max. score:
0
Reversibility:
fully reversible within: 1
Irritation parameter:
iris score
Basis:
animal #3
Remarks:
(mean score 3)
Time point:
other: overall at 24, 48 and 72 h
Score:
0
Max. score:
0
Reversibility:
fully reversible within: 1
Irritation parameter:
iris score
Basis:
other: max score
Time point:
other: overall
Score:
0
Max. score:
0
Remarks on result:
other: Max. duration: 72 h; Max. value at end of observation period: 0(related to all animals)
Irritant / corrosive response data:
Reversibility of any observed effect: Changes fully reversible within 1 days

Applicant's summary and conclusion

Interpretation of results:
other: not classified