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Diss Factsheets
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EC number: 203-379-2 | CAS number: 106-26-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Acute oral toxicity: LD50 rat 6800 mg/kg
Acute dermal toxicity: LD50 rat > 2000 mg/kg bw
Key value for chemical safety assessment
Additional information
Acute oral toxicity:
In the key study, citral was given to male and female Sprague Dawley rats (5 per dose) by gavage with carboxy methyl cellulose as vehicle at doses ranging from 2150 to 10 000 mg/kg bw. The oral LD50 was ca. 6800 mg/kg bw. Death occurred within several days and was preceeded by clinical signs of intoxication, i.e. salivation, apathy, staggering, abdominal and lateral position, atony, narcotic state and no pain reflex before death, ruffled fur and poor general condition (BASF 1978).
In a supportive gavage study in female rats (vehicle gum arabic, observation period 2 days), LD50 values were 4895 mg/kg (BASF 1957).
Further LD50 values are available as publications from secondary sources. LD50 values reported for rats were 4960 mg/kg (Jenner 1964) and 4960 mg/kg (Baer 1967).
In an acute oral toxicity study in male mice an LD50 of 1424 mg/kg has been determined (BASF 1957). Further studies, available as publications from secondary sources, do not confirm this LD50 value but reported LD50 values at approx. 2000 mg/kg bw or higher, e.g. LD50=6000 mg/kg (RTECS 1940).
Acute inhalation toxicity:
No key study is available, however, supportive evidence from an inhalation hazard test does not indicate an acute inhalative toxicity of citral, and a study on acute dermal toxicity, covering a relevant route of exposure, is available.
In a supportive study, i.e. an standardized inhalation hazard test, 12 Sprague Dawley rats each were exposed for 7 hours to an atmosphere that had been saturated with the volatile parts of the test compound (vapour) at 20°C (BASF 1978). 0/12 rats died after 7 h exposure at 20°C. No clinical signs or adverse findings in gross pathology were observed.
Acute dermal toxicity:
In the chosen key study, no mortality or signs of intoxication occurred in 3 male or 3 female Sprague-Dawley rats during a 14-day observation period after a single dermal treatment with 2000 mg/kg (BASF 1978). For a supporting study (Moreno 1974; data from secondary source, reliability not assignable), a dermal LD50 of 2250 mg/kg was reported in rabbits.Justification for classification or non-classification
Acute toxicity oral: Based on the key study (BASF 1978) with a LD50 value of 6800 mg/kg in the rat as relevant species for classification, a non- classification according to the criteria laid down in 67/548/EEC and 1272/2008/EEC is warranted. According to UN-GHS, the test substance needs to be classified as acute oral toxicant (Category 5).
Acute toxicity dermal: The present data on acute dermal toxicity do not fulfill the criteria laid down in 67/548/EEC and 1272/2008/EEC, and therefore, a non-classification is warranted. According to UN-GHS, the test substance needs to be classified as acute dermal toxicant (Category 5).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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