2-Propen-1-one, 3-(dimethylamino)-1-(3-pyridinyl)-

Biodegradation in water: screening tests

Administrative data

Endpoint:

biodegradation in water: ready biodegradability

Type of information:

experimental study

Adequacy of study:

key study

Study period:

September 01, 1999-October 21, 1999

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: This study has been performed according to OECD and/or EC guidelines and according to GLP principles

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1999

Report date:

1999

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method C.4-C (Determination of the "Ready" Biodegradability - Carbon Dioxide Evolution Test)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Test material

Test material information

Constituent 1

Reference substance name:

3-Dimethylamino-1-(3-pyridinyl)-2-propen-1-one

Cas Number:

55314-16-4

Molecular formula:

C10 H12 N2 O

IUPAC Name:

3-Dimethylamino-1-(3-pyridinyl)-2-propen-1-one

Details on test material:

Name of test material (as cited in study report): STI571 Y5a
- Substance type: Brown solid
- Physical state: Solid
- Analytical purity: 98.6%
- Expiration date of the lot/batch: 01 July 2001
- Stability under storage conditions: Stable
- Storage condition of test material: In refrigerator in the dark
- Solubility in water: Not indicated

Study design

Oxygen conditions:

aerobic

Inoculum or test system:

activated sludge, domestic, non-adapted

Duration of test (contact time):

28 d

Initial test substance concentration

Initial test substance concentration 1

Initial conc.:

12 mg/L

Based on:

other: Total Organic Carbon (TOC)

Initial test substance concentration 2

Initial conc.:

17.5 mg/L

Based on:

test mat.

Results and discussion

% Degradation

Parameter:

% degradation (CO2 evolution)

Value:

50

Sampling time:

29 d

Remarks on result:

other: HCl added on the 28th day (last CO2-measurement on the 29th day)

Details on results:

In the toxicity control more than 25% degradation occurred within 14 days (based on ThCO2). Therefore, the test substance was assumed to be not inhibitory.

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Interpretation of results:

other: STI571 Y5A was degraded significantly (50 and 58%) However, since at least 60% biodegradation was not reached within 28 days, within ten days of biodegradation exceeding 10%, the criterion for ready biodegradability was not met.

Conclusions:

The test material was degraded significantly during the test period. However, since at least 60% biodegradation was not reached within 28d, within10 d of biodegradation exceeding 10%, the criterion for ready biodegradability was not met. Thus, under the conditions of this test the test material was not readily biodegradable.