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EC number: 233-135-0 | CAS number: 10043-01-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction
Administrative data
- Endpoint:
- multi-generation reproductive toxicity
- Remarks:
- based on test type (migrated information)
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Reliable without restrictions. Well-presented study, with relevant measurement of chemical concentrations
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 966
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.35 (Two-Generation Reproduction Toxicity Test)
- GLP compliance:
- not specified
- Limit test:
- yes
Test material
- Reference substance name:
- Aluminium chloride
- EC Number:
- 231-208-1
- EC Name:
- Aluminium chloride
- Cas Number:
- 7446-70-0
- IUPAC Name:
- aluminum trichloride
- Details on test material:
- Name of test material:others-aluminium chloride
Name of test material: Aluminium chloride
- CAS Number: 7446-70-0
- EC Number: 231-208-1
- Molecular formula (if other than submission substance): AlCl3
- Molecular weight (if other than submission substance): 133.34 g/mol
- Smiles notation (if other than submission substance): Cl[Al](Cl)Cl
- InChl (if other than submission substance):= InChI=1/Al.3ClH/h;3*1H/q+3;;;/p-3
- Structural formula attached as image file (if other than submission substance): see Fig.1
- Substance type:inorganic
- Physical state:solid
- Appearance: white or pale yellow solid, hygroscopic
- Density – 2.48 g/cm3
- Melting point- 192.4 °C
- Solubility in water - 43.9 g/100 ml (0 °C), 44.9 g/100 ml (10 °C), 45.8 g/100 ml (20 °C),46.6 g/100 ml (30 °C), 47.3 g/100 ml (40 °C), 48.1 g/100 ml (60 °C), 48.6 g/100 ml (80 °C), 49 g/100 ml (100 °C
- Solubility: soluble in hydrogen chloride, ethanol, chloroform, carbon tetrachloride slightly soluble in benzene
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: Dobra Voda
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: drinking water
- Type of inhalation exposure (if applicable):
- whole body
- Vehicle:
- water
- Details on exposure:
- The chronic toxicity was studied in a reproduction experiment on white mice. Ten mice received aluminium chloride in their drinking water, receiving on the average 19.3 mg Al/kg./day. They were compared with to control mice. The experiment lasted 180 to 390 days, during which weight increases, number of litters, and number of off-spring were recorded.
- Details on mating procedure:
- The weanlings were treated from 4 weeks of age like their parents. At the end of the experiment the animals were killed by decapitation, the blood was examined for changes in the red cell count, and the liver, spleen, and kidneys were examined histologically.
- Duration of treatment / exposure:
- Exposure period: 180 - 390 d (weanlings were treated from 4.week of age like parents)
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0; 19.3 mg/kg/d (doses expressed in terms of Al)
Basis:
- No. of animals per sex per dose:
- 10
- Control animals:
- yes
- Positive control:
- No
Examinations
- Parental animals: Observations and examinations:
- CAGE SIDE OBSERVATIONS: Yes
- Time schedule: daily
DETAILED CLINICAL OBSERVATIONS: Yes
- Time schedule: daily
BODY WEIGHT: Yes
- Time schedule for examinations: daily
WATER CONSUMPTION AND COMPOUND INTAKE (if drinking water study): Yes
- Time schedule for examinations:daily
- Oestrous cyclicity (parental animals):
- not examined
- Sperm parameters (parental animals):
- not examined
- Litter observations:
- STANDARDISATION OF LITTERS
- Performed on day 4 postpartum: no
PARAMETERS EXAMINED
The following parameters were examined in [F1 / F2 / F3] offspring: yes
There were no significant differences in the numbers of litters or off-spring between the treated and control mice. Growth was retarded and was dependent on the intake of aluminium, but the effect did not appear in the first generation or in the first litter. The subsequent litters manifested a very marked growth retardation, as did those of the third generation
GROSS EXAMINATION OF DEAD PUPS:no - Postmortem examinations (parental animals):
- The weanlings were treated from 4 weeks of age like their parents. At the end of the experiment the animals were killed by decapitation, the blood was examined for changes in the red cell count, and the liver, spleen, and kidneys were examined histologically.
- Postmortem examinations (offspring):
- The weanlings were treated from 4 weeks of age like their parents. At the end of the experiment the animals were killed by decapitation, the blood was examined for changes in the red cell count, and the liver, spleen, and kidneys were examined histologically.
- Statistics:
- An analysis of variance (Weber, 1964) established that, under the conditions of our experiment, weight variations could be accounted for by aluminium uptake (p < 0.001). The differences in the course of weight plots for successive generations and litters were also statistically Significant (p <0.01).
Results and discussion
Results: P0 (first parental generation)
General toxicity (P0)
- Clinical signs:
- effects observed, treatment-related
- Body weight and weight changes:
- effects observed, treatment-related
- Food consumption and compound intake (if feeding study):
- effects observed, treatment-related
- Organ weight findings including organ / body weight ratios:
- effects observed, treatment-related
- Histopathological findings: non-neoplastic:
- effects observed, treatment-related
- Other effects:
- effects observed, treatment-related
Reproductive function / performance (P0)
- Reproductive function: oestrous cycle:
- not examined
- Reproductive function: sperm measures:
- not examined
- Reproductive performance:
- no effects observed
Details on results (P0)
Growth was retarded and was dependent on the intake of aluminium, but the effect did not appear in the first generation or in the first litter.
The subsequent litters manifested a very marked growth retardation, as did those of the third generation . An analysis of variance , under the conditions of this experiment, weight variations could be accounted for by aluminium uptake (p < 0.001).
The differences in the course of weight plots for successive generations and litters were also statistically Significant (p <0.01
The erythrocyte counts and haemoglobin levels in the first and last generations did not differ significantly from those in the controls; and no pathological changes could be found in the tissues examined.
Effect levels (P0)
- Dose descriptor:
- NOAEL
- Effect level:
- 310 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: overall effects: The subsequent litters manifested a very marked growth retardation, as did those of the third generation
- Remarks on result:
- other: Generation: F3 (migrated information)
Results: F1 generation
General toxicity (F1)
- Clinical signs:
- effects observed, treatment-related
- Mortality / viability:
- mortality observed, treatment-related
- Body weight and weight changes:
- effects observed, treatment-related
- Sexual maturation:
- not examined
- Organ weight findings including organ / body weight ratios:
- effects observed, treatment-related
- Gross pathological findings:
- effects observed, treatment-related
- Histopathological findings:
- effects observed, treatment-related
Details on results (F1)
Growth was retarded and was dependent on the intake of aluminium, but the effect did not appear in the first generation or in the first litter.
The subsequent litters manifested a very marked growth retardation, as did those of the third generation . An analysis of variance , under the conditions of this experiment, weight variations could be accounted for by aluminium uptake (p < 0.001).
The differences in the course of weight plots for successive generations and litters were also statistically Significant (p <0.01
The erythrocyte counts and haemoglobin levels in the first and last generations did not differ significantly from those in the controls; and no pathological changes could be found in the tissues examined.
Effect levels (F1)
- Dose descriptor:
- NOAEL
- Generation:
- F1
- Effect level:
- 310 mg/kg bw/day
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: see 'Remark'
Results: F2 generation
Effect levels (F2)
- Dose descriptor:
- NOAEL
- Generation:
- F2
- Effect level:
- 310 mg/kg bw/day
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: see 'Remark'
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Any other information on results incl. tables
RS-Freetext:
There were no significant differences in the numbers of
litters or off-spring between the treated and control
mice. Growth was retarded and was dependent on the intake
of aluminium, but the effect did not appear in the first
generation or in the first litter. The subsequent litters
manifested a very marked growth retardation, as did those
of the third generation. An analysis of variance
established that, under the conditions of our experiment,
weight variations could be accounted for by aluminium
uptake (P < 0.001). The differences in the course of weight
plots for successive generations and litters were also
statistically significant (P < 0.01).
The erythrocyte counts and haemoglobin levels in the
first and last generations did not differ significantly
from those in the controls; and no pathological changes
could be found in the tissues examined.
Applicant's summary and conclusion
- Conclusions:
- The NOAEL (No Observed Adverse Effect Level) for effects on off-spring growth was 310 mg/kg/bw/day.
Growth was retarded and was dependent on the intake of aluminium, but the effect did not appear in the first generation or in the first litter. The subsequent litters manifested a very marked growth retardation, as did those of the third generation.
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