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EC number: 700-518-3 | CAS number: 38233-76-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 06 June 1989 - 27 June 1989
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to OECD test guidelines, and in compliance with GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- (3R,6S,9E)-9-ethylidenetetracyclo[6.2.1.1³,⁶.0²,⁷]dodec-4-ene; (3S,6R,9E)-9-ethylidenetetracyclo[6.2.1.1³,⁶.0²,⁷]dodec-4-ene
- EC Number:
- 700-518-3
- Cas Number:
- 38233-76-0
- Molecular formula:
- C14H18
- IUPAC Name:
- (3R,6S,9E)-9-ethylidenetetracyclo[6.2.1.1³,⁶.0²,⁷]dodec-4-ene; (3S,6R,9E)-9-ethylidenetetracyclo[6.2.1.1³,⁶.0²,⁷]dodec-4-ene
- Details on test material:
- - Name of test material (as cited in study report): ED-TCD
- Chemical name cited in report: 2-ethylidene-1,2,3,4,4a,5,8,8a-octahydro-1,4:5,8-dimethano-naphthalene
- Physical state: Clear liquid
- Analytical purity: 99.3%
- Storage condition of test material: Refrigerated (c. 4°C)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 7 Weeks (5 weeks at receipt, then 2 weeks' acclimatization)
- Weight at study initiation: Males: 147 - 208 g; Females: 124 to 154 g
- Housing: Stainless steel cages with wire-screen bottom and front
- Diet (e.g. ad libitum): free access to cereal-based, open formula basal diet for rats
- Water (e.g. ad libitum): free access to tap water
- Acclimation period: 2 weeks
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 24°C
- Humidity (%): 30 - 70%
- Air changes (per hr): 10 per hour
- Photoperiod (hrs dark / hrs light): 12 hours light / 12 hours dark
IN-LIFE DATES: (Main study) From: 06 June 1989 To: 20 June 1989
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- maize oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 33.7 - 256.2 mg/mL
- Amount of vehicle (if gavage): 10 mL/kg bodyweight
- Justification for choice of vehicle: Determined during a preliminary study (results of which were not presented)
MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg - Doses:
- 337, 506, 759, 1139, 1709, 2562 mg/kg bodyweight
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Bodyweights recorded on days 0, 3, 7, and 14. The rats were observed regularly for signs of intoxication, during the first 4 hours after treatment and thereafter, at least once daily through an observation period of 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, gross pathology. - Statistics:
- LD50 calculated by Finney method (Finney, D.J., Probit Analysis, Cambridge University Press, 3rd Edition, 1971).
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 849 mg/kg bw
- 95% CL:
- 658 - 1 068
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 666 mg/kg bw
- 95% CL:
- 488 - 895
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 089 mg/kg bw
- 95% CL:
- 804 - 1 471
- Mortality:
- Males: all animals died in the 1139, 1709, and 2562 mg/kg dose levels; 2 out of 5 animals died in the 507 and 759 mg/kg dose levels. No animals died in the 337 mg/kg level.
Females: All rats died at 2562 mg/kg, and 4 out of 5 rats died at the 1709 mg/kg dose level. Two out of five rats died at the 759 and 1139 mg/kg dose levels, and no rats died at the 507 mg/kg level.
At all dose levels, deaths occurred within 2 days of treatment with the test material. - Clinical signs:
- other: Sluggishness, piloerection and diarrhoea were all seen within one hour of treatment in the highest dose level. Later in the observation period, symptoms such as tremor, soiled furs, coma and pallour were noted.
- Gross pathology:
- Macroscopic examination of the animals that died and of the animals which survived did not reveal treatment-related changes in any of the dose levels.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 of ED-TCD by oral administation in rats was determined to be 666 mg/kg in males (95% confidence limit 488-895), 1089 mg/kg in females (95% confidence limit 804 - 1471), and 849 mg/kg (95% confidence limit 658 - 1068) overall (ignoring the sex difference).
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