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EC number: 407-920-5 | CAS number: 6390-69-8 CA 16-178
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study (GLP; test substance applied on a gauze patch of 12-16 instead of approx. 6 cm2)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- May 12, 1981; because no reactions were observed at 24 hours to 72 hours after removing the bandages, the test was ended after the 72 hours evaluation.
- Deviations:
- yes
- Remarks:
- test substance applied on a gauze patch of 12-16 instead of approx. 6 cm2
- GLP compliance:
- yes
Test material
- Reference substance name:
- 3,3',5,5'-tetra-tert-butylbiphenyl-2,2'-diol
- EC Number:
- 407-920-5
- EC Name:
- 3,3',5,5'-tetra-tert-butylbiphenyl-2,2'-diol
- Cas Number:
- 6390-69-8
- Molecular formula:
- C28 H42 O2
- IUPAC Name:
- 3,3',5,5'-tetra-tert-butyl-[1,1'-biphenyl]-2,2'-diol
- Details on test material:
- - Name of test material (as cited in study report): generic name CA 16-178
- Physical state: solid, powder
- Analytical purity: 97.7% (not specified in the study [Lab. sample], transfered from 28d study [BASF SE [Ciba-Geigy Ltd/884619]], with same Lot/batch)
- Lot/batch No.: A 88103 / Z 1572R
- Storage condition of test material: room temperature
- Other: gloves and face masks as safety precautions
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Kleintierfarm Madoerin AG, CH-4414 Fuellinsdorf
- Age at study initiation: approx. 12-14 weeks old
- Weight at study initiation: 2070 - 2150 g
- Housing: individually in metal cages
- Diet (e.g. ad libitum): standard rabbit pellet - Nafag No. 814, Gossau, Switzerland; ad libitum
- Water (e.g. ad libitum): fresh water; ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20± 3°C
- Humidity (%): 30 - 70%
- Photoperiod (hrs dark / hrs light): 12 / 12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- other: gauze patches were moistened before application with distilled water
- Controls:
- other: untreated skin site of the same animal
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 g - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 72 hours (because no reactions were observed at 24 hours to 72 hours after removing the bandages, the test was ended after the 72 hours evaluation).
- Number of animals:
- 3 (all females)
- Details on study design:
- TEST SITE
- Area of exposure: an area of at least 36 cm2 was shaved on both flanks of the animals approximately 24 hours before treatment
- % coverage: a gauze patch (approx. 12-16 cm2) bearing the test article was applied to the flank
- Type of wrap if used: the patches were loosely covered with an aluminum foil (approx. 36 cm2) and held in place by an adhesive tape (Isoplast, Isoplast AG, CH-5200 Brugg).
REMOVAL OF TEST SUBSTANCE
- Washing (if done): not specified
- Time after start of exposure: 4 hours
SCORING SYSTEM: the skin reactions were evaluated 1, 24, 48, and 72 hours after removing the gauze patches according to the OECD scoring system.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24-48-72-hour
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24-48-72-hour
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritant / corrosive response data:
- Because no skin reactions were observed (neither erythema nor edema), it can be concluded that the test substance has no skin irritation potency in albino rabbits.
- Other effects:
- No other effects observed; no adverse effects on body weight gain (Table 1)
Any other information on results incl. tables
Table 1: Body weight (g)
Animal |
First animals |
Second animal |
Third animal |
Body weight at start of the test |
2080 |
2150 |
2070 |
Body weight after 3 days (end) |
2080 |
2200 |
2120 |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
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