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EC number: 427-430-5 | CAS number: 54301-26-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- FROM 1997-11-27 TO 1997-12-11
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study, OECD guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- UG-batch 97302300
- IUPAC Name:
- UG-batch 97302300
- Details on test material:
- - appearence: whitye solid
- Quantity received: 100g in a plastic jar
- Received: 1997-11-10
- Laboratory reference: 97-3691
- Homgeneity test: not required for less than 28 days studies
- Storage: at rrom temperature, away from the light
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Supplier: IFFA-CREDO (69210 - L'arbresle, France)
Age, weight: about 6 weeks, weight between 201 g and 207 g (males and 173 g and 175 g (females) at the beginning of the study
Acclimatization: at least 5 days
Housing, diet: 5 animals by sex in polypropylene cages. Complete pelleted rat maintenance diet UAR A04-10 (91360-Epinay sur Orge, France)
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- Animals have been fsted before prior to substance administration by withholding food overnight. They received by gavage, according to the bodyweight, the product diluted with CMC (carboxymethyl cellulose) at 0.5 % (cooper batch F16539) and homogenised with mortar, at the single dose of 2000 mg/kg under a constant volume of 10 mL/kg. The administrated preparation was kept up under magnetic stirring during the treaments.
- Doses:
- 2000 mg/kg body weight
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- 14 days after the exposure, rats were sacrified after barbituric anaesthesia, then autopsied. all abnormailities were recorded.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- Male: >= 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: >= 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- other: Signs of toxicity related to dose levels: No mortality occured No alteration
- Gross pathology:
- Effects on organs:
did not show any visible organic or tissular lesions
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- According to the 67/548/EEC directive, the test substance is unclassified among the substances dangerous if swallowed
- Executive summary:
The aim of this study was to assess the toxicity of the test item UG after a single oral exoposure of 2 000mg/kg body weight.
The rats were observed up to 14 days after the oral dose.
No mortality occured, no clinical sign was observed, individual growth weight of the rats remain normal and regular.
Effects on organs: did not show any visible organic or tissular lesions
Lethal Dose 0% (LD0) of the test substance is higher than 2000 mg/kg body weight.
According to the 67/548/EEC directive, the test substance is unclassified among the substances dangerous if swallowed
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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