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Diss Factsheets
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EC number: 442-450-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 14 - 18 Mar 2003
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- 2001
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- 2001
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Federal Office of Public Health, Bern, Switzerland
- Type of method:
- HPLC estimation method
- Media:
- soil
- Radiolabelling:
- no
- Details on study design: HPLC method:
- EQUIPMENT
- Apparatus: Varian autosampler 9095, Varian pump 9012, Varian detector 9050, Jones column oven 7990
- Type, material and dimension of analytical (guard) column: LiChrospher 100 CN, part, size 5 µm, 250 mm x 4 mm
- Detection system: UV (210 nm for reference items and formamide and 250 nm for test item solutions)
MOBILE PHASES
- Type: LiChrospher 100 CN, part, size 5 /vm, 250 mm x 4 mm
- Experiments with additives carried out on separate columns: yes / no
- pH: 8.5
- Solutes for dissolving test and reference substances: acetonitrile
DETERMINATION OF DEAD TIME
- Method: by means of homologous series: Formamide (50 µL) was diluted to 50 mL with acetonitrile to obtain a stock solution. The stock solution (36 µL) was diluted to 1 mL with acetonitrile. This formamide solution was injected three times for the determination of the dead time of the HPLC system.)
REFERENCE SUBSTANCES
- Identity: phenol, isoproturon, linuron, pyrazophos, Diclofop-methyl, 2,4-DDT (mixed standard)
DETERMINATION OF RETENTION TIMES
- Quantity of test substance introduced in the column: 176.5 µg/mL
- Quantity of reference substances: phenol: 5.5 µg/mL, 5.4 µg/mL isoproturon, 3.6 µg/mL linuron, 39 µg/mL pyrazophos, 8.4 µg/mL diclofop-methyl, 11.6 µg/mL (mixed standard)
- Intervals of calibration:
REPETITIONS
- Number of determinations: 3 (test item), 6 (mixed standard)
EVALUATION
- Calculation of capacity factors k': the capacity factor (k’) is calculated from the retention time of the reference items, the test item (tr) and an unretarded item (t0)
- Determination of the log Koc value: The log k’ value of the test item was used to calculate its log K0c value. - Type:
- log Koc
- Value:
- > 5.63
- Remarks on result:
- other: Limit value based on 2,4-DDT
- Type:
- Koc
- Value:
- >= 1 291 569 - <= 1 406 043 L/kg
- pH:
- 8.1
- Remarks on result:
- other: first peak, extrapolated
- Type:
- log Koc
- Value:
- 6.1 dimensionless
- pH:
- 8.1
- Remarks on result:
- other: first peak, extrapolated
- Type:
- Koc
- Value:
- >= 38 000 000 - <= 47 000 000 L/kg
- pH:
- 8.1
- Remarks on result:
- other: second peak, extrapolated
- Type:
- log Koc
- Value:
- >= 8.6 - <= 8.7 dimensionless
- pH:
- 8.1
- Remarks on result:
- other: second peak, extrapolated
- Details on results (HPLC method):
- - Retention times of reference substances used for calibration (mean values): phenol: 2.89 min, isoproturon: 3.20 min, linuron: 3.62 min, pyrazophos: 4.13 min, Diclofop-methyl: 4.82 min, 2,4-DDT: 6.09 min
- Details of fitted regression line (log k' vs. log Koc): r = 0.990
- Graph of regression line attached: yes
- Average retention data for test substance: Test item peak 1: 7.31 min, test item peak 2: 15.63 min - Validity criteria fulfilled:
- not applicable
Reference
Tale 1: Results of linear regression of Log k' vs. Log Koc
Substances |
Number of analyses |
Mean retention time (min) |
k’ |
Log k‘ |
Log Koc |
Formamide (=dead time) |
3 |
2.17 |
- |
- |
- |
Phenol |
6 |
2.89 |
0.33 |
-0.48 |
1.32 |
Isoproturon |
6 |
3.20 |
0.47 |
-0.32 |
1.86 |
Linuron |
6 |
3.62 |
0.67 |
-0.18 |
2.59 |
Pyrazophos |
6 |
4.13 |
0.90 |
-0.04 |
3.65 |
Diclofop-methyl |
6 |
4.82 |
1.22 |
0.09 |
4.20 |
2,4-DDT |
6 |
6.09 |
1.81 |
0.26 |
5.63 |
Linear regression |
Slope = |
0.167 |
|||
y-axis intercept = |
-0.649 |
||||
Coefficient of regression = |
0.990 |
Table 2: Results of test item analyses
Number of analyses |
Retention time (min) |
k’ |
Log k‘ |
Log Koc |
Mean log Koc |
Koc |
Mean Koc |
1 Test item Peak |
|||||||
1 |
7.28 |
2.35 |
0.37168 |
6.1 |
6.1 |
1291569 |
1343527 |
2 |
7.31 |
2.37 |
0.37397 |
6.1 |
1332967 |
||
3 |
7.35 |
2.39 |
0.37784 |
6.1 |
1406043 |
||
2. Test item Peak |
|||||||
1 |
15.35 |
6.07 |
0.78319 |
8.6 |
8.6 |
3.8E+08 |
4.29E+08 |
2 |
15.69 |
6.23 |
0.79432 |
8.6 |
4.4E+08 |
||
3 |
15.87 |
6.31 |
0.80009 |
8.7 |
4.7E+08 |
Description of key information
Log Koc = 6.1 - 8.7 (OECD 121)
Key value for chemical safety assessment
Additional information
The adsorption coefficient (Koc) of the test item was determined in a GLP study performed according to OECD 121.
The test item solution of 176.5 µg/mL was injected three times. A combined reference substance solution containing phenol, isoproturon, linuron, pyrazophos, Diclofop-methyl and 2,4-DDT was injected six times. The log Koc was calculated using a regression curve (log k' vs. log Koc). The reference items covered the range of log Koc 1.32 to 5.63.
The retention times of the test item in the HPLC chromatogram are longer than the retention time of the highest reference item used. Therefore, the logarithm of the adsorption coefficient of the test item was extrapolated from the regression curve to be 6.1 (first test item peak) and 8.6 (second test item peak). The Koc of the test item were calculated to be 1343527 and 4.3 x 10^8 indicating a strong potential to adsorb to soil and sediment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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