Registration Dossier
Registration Dossier
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EC number: 204-587-6 | CAS number: 122-97-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 431 (In Vitro Skin Corrosion: Reconstructed Human Epidermis (RHE) Test Method)
- Version / remarks:
- July29th, 2016
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 3-phenylpropan-1-ol
- EC Number:
- 204-587-6
- EC Name:
- 3-phenylpropan-1-ol
- Cas Number:
- 122-97-4
- Molecular formula:
- C9H12O
- IUPAC Name:
- 3-phenylpropan-1-ol
- Test material form:
- liquid: viscous
- Remarks:
- clear oily liquid
- Details on test material:
- Compound SMILES: OCCCc1ccccc1
Constituent 1
- Specific details on test material used for the study:
- Batch No.: 10888
In vitro test system
- Test system:
- human skin model
- Remarks:
- The reconstructed human epidermal model EpiDerm™ (EPI-200, MatTek, Ashland, USA); Lot No. 28614, kit B, C
Results and discussion
In vitro
Results
- Irritation / corrosion parameter:
- % tissue viability
- Value:
- 108.1
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (corrosive) based on GHS criteria
- Conclusions:
- In the experiment arrangement described above, the test item 3-phenylpropan-1-ol was corrosive in the EpiDermTM model.
- Executive summary:
Under the experimental design, the average viability of tissues treated with the test item 3-phenylpropan-1-ol was 108.1 % of the negative control average value after 3 minutes treatment and 7.1 % after 60 minutes treatment.
The test item is considered to be corrosive to skin:
ii) if the viability after 3 minutes exposure is greater than or equal to 50 % and the viability after 1 hour exposure is less than 15 %.
In the experiment arrangement described above, the test item 3-phenylpropan-1-ol was corrosive in the EpiDermTM model.
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