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Diss Factsheets
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EC number: 220-474-4 | CAS number: 2778-42-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_environmental-fate-and-pathways.png)
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- other: HPLC column
- Radiolabelling:
- no
- Test temperature:
- 30°C
- Details on study design: HPLC method:
- EQUIPMENT
- Apparatus: Agilent Technologies11 00, incorporating autosampler and workstation
- Type, material and dimension of analytical (guard) column: Column: CN Optimal 5µ (150 x 4.6 mm id); Column temperature: 30°C
- Detection system: UV detector at 210 nm wavelength
MOBILE PHASES
- Type: Methanol:water (55:45 v/v)
- pH: 6.5
- Flow rate: 1.0 mL/min
DETERMINATION OF DEAD TIME
- Method: by inert substance (formamide) which are not retained by the column
REFERENCE SUBSTANCES
- Identity: Acetanilide at 108 mg/L; Phenol at 104 mg/L; Atrazine at 96 mg/L; Isoproturon at 98 mg/L; Triadimenol at 100 mg/L; Linuron at 99 mg/L; Naphthalene at 109 mg/L; Endosulfan-diol at 101 mg/L; α-Endosulfan at 126 mg/L; Phenanthrene at 101 mg/L; Diclofop-methyl at 104 mg/L; DDT at 101 mg/L
- Solvent used for reference substance: Acetonitrile
DETERMINATION OF RETENTION TIMES
- Quantity of test substance introduced in the column: 10µL (test solution preparation: 0.1085 g of test material was diluted to 100 mL with acetonitrile and further diluted by a factor 4)
- Quantity of reference substances: See above under reference substances
- Intervals of calibration: Ten
REPETITIONS
- Number of determinations: Two
EVALUATION
- Calculation of capacity factors k: The capacity factor was determined using: k = (tr-t0)/t0; where, k: Capacity factor; tr: retention time (min); t0: dead time (min)
- Determination of the log Koc value: The adsorption coefficient was calculated using: Log10Koc= (Log10 k-A)/B; where, Koc: adsorption coefficient; k: capacity factor; A: intercept of the calibration curve; B: slope of the calibration curve - Analytical monitoring:
- not required
- Details on sampling:
- Not applicable
- Details on matrix:
- Not applicable
- Details on test conditions:
- Not applicable
- Initial conc. measured:
- other: Not applicable
- Computational methods:
- Not applicable
- Type:
- Koc
- Value:
- 11 400
- Temp.:
- 30 °C
- Remarks on result:
- other: HPLC method: % organic carbon not relevant
- Type:
- log Koc
- Value:
- 4.06
- Temp.:
- 30 °C
- Remarks on result:
- other: Mean value. HPLC method; % organic carbon not relevant
- Details on results (HPLC method):
- For details, see 'Any other information on results incl. tables'
- Adsorption and desorption constants:
- Not applicable
- Recovery of test material:
- Not applicable
- Concentration of test substance at end of adsorption equilibration period:
- Not applicable
- Concentration of test substance at end of desorption equilibration period:
- Not applicable
- Transformation products:
- not measured
- Details on results (Batch equilibrium method):
- Not applicable
- Statistics:
- Not applicable
- Validity criteria fulfilled:
- yes
- Conclusions:
- Under the test conditions, the adsorption coefficient (Koc) of m-TMXDI was determined to be 1.14 x 10(4); log10 Koc = 4.06.
- Executive summary:
An adsorption coefficient (Koc) on soil and sewage sludge was determined for m-TMXDI using the HPLC screening method according to OECD Guideline 121 and EU Method C.19, in compliance with GLP.The test substance (10 µL), dead time (formamide) and reference standard solutions were injected in duplicate into the HPLC columns. The retention time data of the deadtime and reference standard solutions were then used to construct the calibration curve. Based on this curve, the log Koc value of the test substance was determined. Under the study conditions, the adsorption coefficient (Koc) of m-TMXDI was determined to be 1.14 x 10(4) and the log10 Koc was 4.06 (Fox, 2009).
Reference
Table 1: Retention times of formamide
Dead Time | Retention Time (min) | Mean Retention Time (min) | Mean Retention Time (min) |
Injection 1 | Injection 2 | ||
Formamide | 1.951 | 1.948 | 1.95 |
Table 2: Retention times, capacity factors (k) and log10 Koc values for the reference standards
Standard | Retention Time (min) | Mean Retention Time (min) | Capacity Factor (k) | LOG10 k | LOG10 Koc | |
Injection 1 | Injection 2 | |||||
Acetanilide | 2.526 | 2.526 | 2.526 | 0.296 | -0.529 | 1.25 |
Phenol | 2.596 | 2.598 | 2.597 | 0.332 | -0.479 | 1.32 |
Atrazine | 2.956 | 2.963 | 2.96 | 0.518 | -0.286 | 1.81 |
Isoproturon | 3.256 | 3.258 | 3.257 | 0.671 | -0.173 | 1.86 |
Triadimenol | 3.97 | 3.968 | 3.969 | 1.04 | 1.53 x 10-2 | 2.4 |
Linuron | 4.645 | 4.629 | 4.637 | 1.38 | 0.139 | 2.59 |
Naphthalene | 4.317 | 4.309 | 4.313 | 1.21 | 8.36 x 10-2 | 2.75 |
Endosulfan-diol | 5.783 | 5.761 | 5.772 | 1.96 | 0.292 | 3.02 |
α-Endosulfan | 8.334 | 8.335 | 8.335 | 3.28 | 0.515 | 4.09 |
Phenanthrene | 7.214 | 7.211 | 7.213 | 2.7 | 0.431 | 4.09 |
Diclofop-methyl | 8.284 | 8.28 | 8.282 | 3.25 | 0.512 | 4.2 |
DDT | 16.325 | 16.348 | 16.337 | 7.38 | 0.868 | 5.63 |
Table 3: Retention times, capacity factors and log10 Koc values determined for the test material
Injection | Retention Time (min) | Capacity Factor (k) | Log10 k | Log10 Koc |
1 | 7.747 | 2.97 | 0.473 | 4.06 |
2 | 7.743 | 2.97 | 0.473 | 4.06 |
Description of key information
Key value for chemical safety assessment
- Koc at 20 °C:
- 11 400
Additional information
An adsorption coefficient (Koc) on soil and sewage sludge was determined for m-TMXDI using the HPLC screening method according to OECD Guideline 121 and EU Method C.19, in compliance with GLP. The test substance (10 µL), dead time (formamide) and reference standard solutions were injected in duplicate into the HPLC columns. The retention time data of the deadtime and reference standard solutions were then used to construct the calibration curve. Based on this curve, the log Koc value of the test substance was determined. Under the study conditions, the adsorption coefficient (Koc) of m-TMXDI was determined to be 1.14 x 10(4) and the log10 Koc was 4.06 (Fox, 2009).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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