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EC number: 253-775-4 | CAS number: 38083-17-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Daphnia magna was tested in a semi-static test system following OECD guideline no. 211 over 21 days. The NOEC (reproduction) was determined to be 0.2 mg/L and the LOEC (reproduction) was determined to be 0.4 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- NOEC
- Effect concentration:
- 0.2 mg/L
Additional information
The effect of the test substance on the reproduction of Daphnia magna was studied in a valid GLP study according to OECD 211. The test was performed under semi-static conditions over 21 days. The daphnids (10 animals) were exposed to six different concentrations (0.025, 0.05, 0.1, 0.2, 0.4 and 0.8 mg/L). As the test concentrations were stable (analytical verification: recovery 94 to 115%) the effect concentrations were based on nominal concentrations.
The offspring produced by each parent animal were removed and counted daily from the appearance of the first brood. The mean number of living offspring in the test concentrations of 0.025 to 0.2 mg/L were higher than the corresponding control value, whereas it was significantly reduced at the two highest test concentrations (0.4 mg/L: 75.8 % and to 0.8 mg/L: 100 %). Significant reduced No. of living juveniles per parent animal produced per day (from the day of the first offspring on) were obtained with the test groups treated with 0.4 and 0.8 mg/L compared to the untreated control.
The additionally recorded time from the production of first brood until the end of the test showed significant differences of the values at the concentrations of 0.2, 0.4 and 0.8 mg/L from the control.
Besides the offspring counting other parameter were examined: microscopic examination of the newborns, presence of aborted eggs, aborted offspring, dead newborns and behavioral changes.Significantly higher numbers of aborted eggs and dead newborns were noticed in the concentrations of 0.4 and 0.8 mg/L. The presence of male neonates or ephippia was not noticed. Reduced activity of the newborns was noticed at the concentration of 0.2 mg/L.10 % mortality among the parent animals was observed during the testat the concentration of 0.05 mg/L, but as this value was within the acceptance range of the control, it was evaluated as non test item-related effect. No significant difference between the measured body length values of the daphnia exposed to the test substance and the measured values of the untreated animals were found.
The highest concentration tested without showing a toxic effect on reproduction after the 21-day exposure period (=NOEC) was determined as 0.2 mg/L and the determined LOEC was 0.4 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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