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Diss Factsheets
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EC number: 203-977-3 | CAS number: 112-49-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study according to OECD401; no detailed clinical observations reported;
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- only one sex tested, limitations in study reporting
- Principles of method if other than guideline:
- -
- GLP compliance:
- no
- Remarks:
- performed before GLP guidelines
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1,2-bis(2-methoxyethoxy)ethane
- EC Number:
- 203-977-3
- EC Name:
- 1,2-bis(2-methoxyethoxy)ethane
- Cas Number:
- 112-49-2
- Molecular formula:
- C8H18O4
- IUPAC Name:
- 2,5,8,11-tetraoxadodecane
- Details on test material:
- - Name of test material (as cited in study report): Triethylenglykoldimethylether-Hoechst
- Analytical purity: not stated
- physical state: clear colourless liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Strain: SPF-Wistar rats Hoe WISKf(SPF71)
- Source: Hoechst AG Kastengrund - SPF breed
- Weight at study initiation: 190-217 g (female); (mean = 200.4 g, s = ± 6.84 g, n = 30)
- Age at study initiation: no data
- Fasting period before study: 16 hours before and 2 hours after application
- Diet: Altromin 1324 (Fa. Altromin GmbH, Lage/Lippe), ad libitum
- Water: Tap water ad libitum
- Acclimatization period: no data
ENVIRONMENTAL CONDITIONS
- Housing: in groups, in plastic cages, on softwood pellets
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- - concentration in vehicle: 25 % (w/v)
- Doses:
- 4000 mg/kg bodyweight
5000 mg/kg bodyweight
6300 mg/kg bodyweight - No. of animals per sex per dose:
- 10 female rats
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Clinical observations after application / Weighing once weekly
- Necropsy of survivors performed: yes - Statistics:
- Probit analysis (method by Linder and Weber);
Confidence limits according to Fieller
Results and discussion
- Preliminary study:
- Preliminary experiments did not show differences related to gender. Therefore only females used for main study.
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 5 390 mg/kg bw
- 95% CL:
- > 4 860 - < 6 100
- Mortality:
- Sex: female, Dose: 4000 mg/kg bw, Mortality rate: 0 / 10
Sex: female, Dose: 5000 mg/kg bw, Mortality rate: 4 / 10
Sex: female, Dose: 6300 mg/kg bw, Mortality rate: 8 / 10 - Clinical signs:
- other: Following symptoms were observed: Passivity, torpidness, deep anesthesia, disturbance of equilibrium, ataxia, crouch, creeping and ducked position, prone position, lateral position, convulsions, abdomen adducted, flank retracted, hyporeflexia, piloerrecti
- Gross pathology:
- Dissection of rats killed at the end of the observation period revealed punctual reddening on kidney surface.
Necropsy of the deceased animals revealed following macroscopic findings: lungs filled with blood, bladder tight filled with dark-red liquid, surface of liver light spotted, marking of liver lobules, adrenal dicoloured dark-red. - Other findings:
- -
Any other information on results incl. tables
-
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The median lethal dose of Triethyleneglycol dimethylether (LD50) was 5390 mg per kg body weight.
- Executive summary:
The median lethal dose of Triethyleneglycol dimethylether (LD50) was 5390 mg per kg body weight. Based on the result of this study Triethyleneglycol dimethylether is not subject for labelling and classification requirements according to regulatory requirements.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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