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Diss Factsheets
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EC number: 203-977-3 | CAS number: 112-49-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1984
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Method similar to OECD402, differences: only 2 males tested, no details reported
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Dermal toxicity of (...) triethylene glycol dimethyl ether
- Author:
- Clark, B. , Furlong, J., Ladner, A., Slovnak, A.
- Year:
- 1 984
- Bibliographic source:
- IRCD Med. Sci. 12, 296-297, 1984.
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- only one sex tested, only 2 animals per dose tested, limitations in study reporting
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1,2-bis(2-methoxyethoxy)ethane
- EC Number:
- 203-977-3
- EC Name:
- 1,2-bis(2-methoxyethoxy)ethane
- Cas Number:
- 112-49-2
- Molecular formula:
- C8H18O4
- IUPAC Name:
- 2,5,8,11-tetraoxadodecane
- Details on test material:
- - Name of test material (as cited in publication): Triglyme
- Analytical purity: not stated
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
-Strain: COBS/Wistar rats
- Age at study initiation: no data
- Weight at study initiation: 225-306 g (male animals)
- Animalsa caged singly
Administration / exposure
- Type of coverage:
- other: non-occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: shaved, ca. 20 - 25% of the body surface on the backs and the flanks of the animals - Duration of exposure:
- no data
- Doses:
- 1.7 g/kg body weight
3.5 g/kg body weight
6.9 g/kg body weight - No. of animals per sex per dose:
- 2 males
- Control animals:
- no
- Details on study design:
- The tests used a non-occluded technique.
Volumes of the compound (0.1 ml to 2.0 ml maximum) were applied to shaved areas (approximately 20-25% of the body surface) on the backs and the flanks of the animals. "Toby" collars prevented grooming and the contaminated areas were not covered.
Animals were caged singely under normal conditions. - Statistics:
- not required
Results and discussion
- Preliminary study:
- no preliminary study performed
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 6 900 mg/kg bw
- Mortality:
- No mortality
- Clinical signs:
- other: no effects observed
- Gross pathology:
- no data
- Other findings:
- No further findings
Any other information on results incl. tables
-
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The median lethal dose (LD50) of triethylene glycol dimethylether for the dermal route of application is greater 6900 mg/kg body weight in male rats.
- Executive summary:
The median lethal dose (LD50) of triethylene glycol dimethylether for the dermal route of application is greater 6900 mg/kg body weight in male rats. No classification is warranted for triethylene glycol dimethylether.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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