Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

developmental toxicity
Type of information:
calculation (if not (Q)SAR)
Migrated phrase: estimated by calculation
Adequacy of study:
weight of evidence
2 (reliable with restrictions)

Data source

Reference Type:
other: Classification tool software

Materials and methods

Principles of method if other than guideline:
The UVCB substance as complex substance is classified by applying the rules for classification of mixtures (EU CLP guidance section 3.7.2 pg 322ff). The classification criteria (as set out in EU CLP Guidance Annex I: 3.7.1 pg 322) can be used to estimate effects derived from that classification/hazard.

Test material

Constituent 1
Reference substance name:
Calcines, lead-zinc ore conc.
EC Number:
EC Name:
Calcines, lead-zinc ore conc.
Cas Number:
Product of the reaction of zinc & lead ore concentrates wit air at high temperature, consisting mainly of ZnO, ZnFeO2, PbO-PbSO4, a composite of metallic oxides and some residual sulfides and sulphates

Results and discussion

Results (fetuses)

Fetal abnormalities

not specified

Overall developmental toxicity

Developmental effects observed:
not specified

Any other information on results incl. tables

The calculated classification via mixture rules resulted in "reproductive toxicity: category 1A", triggered by lead compounds with total quantity > 0.3% for worts case.

Applicant's summary and conclusion

The tool provided a conclusive "Reproductive toxicity Cat1A" of teh UVCB sample, derived on basis of the mixture toxicity rules for a worst case across industry.