Registration Dossier
Registration Dossier
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EC number: 221-259-8 | CAS number: 3048-64-4
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
There is no available information on toxicokinetics and metabolism of this substance. However, VNB has a log Pow of 3.39, a water solubility of around 100 mg/L, a vapor pressure of 1.65 kPa and a molecular weight of 120. Both the log Pow and water solubility favor absorption, and the toxicity seen in acute studies indicates that the compound is absorbed via the oral, dermal and inhalation routes of exposure. The low molecular weight and a finite water solubility suggest that VNB is likely to be widely distributed throughout the body following intake, a fact that is confirmed from the available data on a similar substance (Ethylidene norbornene - ENB) where systemic effects are seen in a variety of organs after repeated administration via oral or inhalation dosing, including the kidney, thyroid, and liver effects. No information regarding excretion of VNB can be extracted from the available data, although the ratio of the oral LD50 to the dermal LD50 suggests that uptake through the skin is probably no more than 30 -35%.
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