Registration Dossier
Registration Dossier
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EC number: 446-220-4 | CAS number: 365411-50-3
Endpoint summary
Administrative data
Description of key information
Additional information
- Abiotic degradation:
Air:Based on estimation with the QSAR model Aopwin, Nebulone undergoes in air rapid degradation after reaction with hydroxyl radicals (the decrease with ozone could not be calculated). The DT50 values after reaction with hydroxyl radicals is 4 hours. The half-life time of the substance is < 2 days. The substance will not reach the stratosphere and is therefore not considered to be a long-range transported chemical in air (http://www.unece.org/fileadmin/DAM/env/documents/2000/ece/eb/ece%20eb%20air.60.e.pdf).
The substance does not have an ozone depletion potential because it does not contain halogens and does not have the potential to reach the stratosphere (CLP, 2008, Part 5).
Water: In an OECD TG 111 hydrolysis test, the substance showed to be hydrolytically stable at pH 7; the DT50 is thus > 1 year.
- Biotic degradation:
In a screening study according to OECD TG 301B 66% biodegradation was found after 29 days. This study shows that the substance is readily biodegradable under the conditions of this test in view of the substance being a multi-constituent for which the 10 -day window does not apply.
- Bioaccumulation:
Nebulone is expected to have some bioaccumulation potential using the log Kow of 4.29 as a key parameter for the prediction of the BCF for aquatic and terrestrial organisms, which results in values of 884 and 235 L/kg ww, respectively.
- Transport and distribution:
The substance is a moderately lipophilic substance with a log Kow of 4.29. The sorption to organic matter has been determined and the log Koc value is 3.83. This indicates that the substance will have a moderate potential to adsorb to sediment/soil.
To assess the volatilisation potential of the substance a Henry's law constant was calculated which gave a result of 6.3 Pa. m3/mol at 25°C. From the distribution modelling results it can be concluded that volatilisation is of minor importance in the environmental behaviour of the substance. At environmental conditions of 12oC the value will be 3 Pa. m3/mol.
Based on Level III distribution modelling using EPISUITE (assuming equal and continuous releases to air, water and soil) using the Smiles notation: CC2(C)C(C)C(C)(C)C=1C3OCOCC3CCC=12 and the measured physico-chemical parameters as input, it is estimated that the majority of the substance released to the environment will partition mainly into soil (83.1%) and water (15.8%) with small amounts to sediment and air (both <1%). The ready biodegradability of the substance could not be considered here.
The SimpleTreat model, which is incorporated in EUSES, simulates the distribution of the substance in a Sewage Treatment Plant based on vapour pressure, water solubility, log Kow and biodegradability. The model predicts that 56.7% of the substance will be degraded and the remaining part will mainly partition to sludge (33.8%), with minor parts going to water (8.78%) and air (<1%).
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