Registration Dossier
Registration Dossier
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EC number: 446-220-4 | CAS number: 365411-50-3
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 0.038 mg/L
- Assessment factor:
- 50
- Extrapolation method:
- assessment factor
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0.004 mg/L
- Assessment factor:
- 500
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 32 mg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 25.8 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 2.58 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 5.14 mg/kg soil dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential to cause toxic effects if accumulated (in higher organisms) via the food chain
Additional information
Conclusion on classification
Short-term toxicity tests for fish, Daphnia and algae are available for the substance. In addition, two reliable EC10/NOEC values are available for long-term toxicity. The EC50 and LC50 value are between 1 and 10 mg/l, whereas the lowest EC10 is 1.9 mg/L for algae. As two reliable long-term toxicity endpoints are available chronic classification needs to be derived on both acute and chronic data and worst case should be taken. The substance is readily biodegradable, has a log Kow of 4.29 and acute data are between 1 -10 mg/L which would lead to classification as chronic 2 (H411). Based on chronic data Nebulone does not need to be classified. As the worst case needs to be taken Nebulone needs to be classified R51/53 according to Directive 67/548/EEC (DSD). The corresponding classification according to Regulation 1272/2008/EC (CLP) is H411 (Aquatic Chronic 2).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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