Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 221-496-7 | CAS number: 3120-74-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
Materials and methods
- Principles of method if other than guideline:
- Guideline not specified.
- GLP compliance:
- no
Test material
- Reference substance name:
- 4-(methylthio)-m-cresol
- EC Number:
- 221-496-7
- EC Name:
- 4-(methylthio)-m-cresol
- Cas Number:
- 3120-74-9
- Molecular formula:
- C8H10OS
- IUPAC Name:
- 3-methyl-4-(methylsulfanyl)phenol
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Albino
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Duration of treatment / exposure:
- 1, 2, 4, 8, 24 h
- Observation period:
- 7 days
- Number of animals:
- 2
Results and discussion
In vivo
- Other effects:
- Reddening and slight corrosion of the test site.
Any other information on results incl. tables
Bei Abnahme der Verbande nach 1 oder 2 Stunden zeigte die Haut der Applikationsstelle eine leichte Rotung, und Veratzung,
Befand sich das Muthylmercaptokresol fxir 4, 8 oder 24 Studen auf der Haut, dann trat an der Applikationsstelle eine
deutllche Rotung und leichte Veratzung auf, Diese Hautveranderungen waren 7 Tage nach der Applikation noch in der
gleichen Starke vorhanden wie am ersten Tag nach der Applikation.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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