Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 221-496-7 | CAS number: 3120-74-9
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
Materials and methods
- Principles of method if other than guideline:
- Guideline not specified.
- GLP compliance:
- no
Test material
- Reference substance name:
- 4-(methylthio)-m-cresol
- EC Number:
- 221-496-7
- EC Name:
- 4-(methylthio)-m-cresol
- Cas Number:
- 3120-74-9
- Molecular formula:
- C8H10OS
- IUPAC Name:
- 3-methyl-4-(methylsulfanyl)phenol
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: Albino
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Duration of treatment / exposure:
- no data
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 2
Results and discussion
Any other information on results incl. tables
Schon 1 Stunde nach der Applikation waren die Lidbindehaute der behandelten Augen stark gerotet und sehr stark geschwollen. 2 Tage nach der Applikation war auch die Cornea leicht getrubt und die Iris leicht verandert, 7 Tage nach der Applikation waren
diese Veranderungen in etwas abgeschwachter Form immer noch vorhanden.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2A (irritating to eyes)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
