Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
basic toxicokinetics
Type of information:
other: Toxicokinetic assessment
Adequacy of study:
key study
Study period:
April 2012 to May 2012
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Toxicokinetic assessment

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
2012

Materials and methods

Objective of study:
toxicokinetics
Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Toxicokinetic assessment, based on
- Guidance on information requirements and chemical safety assessment Chapter R.7c: Endpoint specific guidance
- ECB EU Technical Guidance Document on Risk Assessment, 2003
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
(+)-L-arginine hydrochloride
EC Number:
214-275-1
EC Name:
(+)-L-arginine hydrochloride
Cas Number:
1119-34-2
Molecular formula:
C6H14N4O2.ClH
IUPAC Name:
(2S)-2-amino-5-carbamimidamidopentanoic acid hydrochloride

Results and discussion

Main ADME results
Type:
absorption
Results:
Oral route: 100%. Dermal route: 10 %. Inhalation route: 100 %

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): other: The absorption factors for risk assessment purposes have been set as follows: absorption oral 100%, absorption dermal 10% and absorption inhalation 100 %
For risk assessment purposes:
Absorption oral: 100%,
Absorption dermal: 10%
Absorption inhalation: 100 %