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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Effect of Selected Amino Acids on Toxicity in Rats
Author:
Breglia, R., Ward, C., Jarowski, C.
Year:
1973
Bibliographic source:
Journal of Pharmaceutical Sciences, 62(1), 49-55

Materials and methods

Principles of method if other than guideline:
Scientific examination
GLP compliance:
no
Remarks:
study performed prior to implementation of GLP
Test type:
other: Scientific examination
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
(+)-L-arginine hydrochloride
EC Number:
214-275-1
EC Name:
(+)-L-arginine hydrochloride
Cas Number:
1119-34-2
Molecular formula:
C6H14N4O2.ClH
IUPAC Name:
(2S)-2-amino-5-carbamimidamidopentanoic acid hydrochloride

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Age at study initiation: 125 - 150 g
- Weight at study initiation: ca. 2 months
- Fasting period before study: 1day
- Housing: no data
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 1 week

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Details on oral exposure:
VEHICLE
- Amount of vehicle (if gavage): 6 ml
- Concentration in vehicle: 140 mg/kg, 2310 mg/kg
- Justification for choice of vehicle: Destilled water has no impact on its own

MAXIMUM DOSE VOLUME APPLIED: 6 ml
Doses:
140 mg/kg, 2310 mg/kg
No. of animals per sex per dose:
5 per dose
Control animals:
yes

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
12 400 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: OECD GHS
Conclusions:
LD50 of L-argine-HCl was determined to be 12400 mg/kg b.w. in a scientific study with rats.