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EC number: 931-285-8
CAS number: -
The generational reproductive study was conducted at levels up to 20000
mg/m3, approximately half of the lower explosive limit, and the highest
level considered safe for use in the laboratory. VRU gasoline did not
produce any pathologic changes in reproductive organs. Additionally,
there were no differences in mating, fertility, live births, birth
weights, and survival or weight gain through weaning. Finally, there
were no differences in sperm count, sperm quality, estrous cycling,
quantification of primordial oocytes, or developmental landmarks, other
than a delay in hair growth in some treated offspring.
There were weight and histopathological changes noted in the kidneys of
the high-dose (20000 mg/m3) exposed males from the second parental
generation, as well as microscopic evidence of hyaline droplets in the
male rat kidneys from both generations. However, as the weight
difference was slight (<6%), found only in one generation, and seen only
in the males, it was not considered to be adverse. The microscopic
changes were consistent with an alpha-2u globulin-mediated process that
is unique to male rats and not toxicologically relevant to humans.
Based on the data reported, the reproductive NOAEL as defined by this
study is >20000 mg/m3.
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